MLL5 contributes to hematopoietic stem cell fitness and homeostasis
about
Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunctionMLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1Mll5 is required for normal spermatogenesisMolecular basis for chromatin binding and regulation of MLL5Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemiaMLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with BorealinUpSET-ting the balance: modulating open chromatin features in metazoan genomes.Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry.Trithorax group proteins: switching genes on and keeping them active.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people.Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.Solution NMR structure and histone binding of the PHD domain of human MLL5.Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions.Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1)MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation.A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.Histone H3 lysine 4 (H3K4) methylation in development and differentiationupSET, the Drosophila homologue of SET3, Is Required for Viability and the Proper Balance of Active and Repressive Chromatin Marks.Epigenetic regulation of development by histone lysine methylation.Update on cytogenetic and molecular changes in myelodysplastic syndromes.Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.3q26/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review.Therapy-related myeloid neoplasms: when genetics and environment collide.MLL5 (KMT2E): structure, function, and clinical relevance.KMT2E-ASNS: a novel relapse-specific fusion gene in early T-cell precursor acute lymphoblastic leukemia.MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy.Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity.Newly emerged isolated Del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasms'-GlcNAc Code' Mediated Biological Functions of Downstream Proteins
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MLL5 contributes to hematopoietic stem cell fitness and homeostasis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
@en
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
@nl
type
label
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
@en
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
@nl
prefLabel
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
@en
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
@nl
P2093
P2860
P1433
P1476
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
@en
P2093
Jasmine Wong
Kevin M Shannon
Mark Klinger
Mary T Tran
Nigel Killeen
P2860
P304
P356
10.1182/BLOOD-2008-05-159905
P407
P577
2008-09-25T00:00:00Z