Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing - Wikidata - awgldk - TriplyDB

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

http://www.wikidata.org/entity/Q37102932

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Customizing the genome as therapy for the β-hemoglobinopathies Progress and promise in understanding the genetic basis of common diseases Genomic approaches to identifying targets for treating β hemoglobinopathies Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies Pluripotent stem cells in research and treatment of hemoglobinopathies Sickle cell disease in children Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients Anemia: progress in molecular mechanisms and therapies Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.Animal models of β-hemoglobinopathies: utility and limitations β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies Therapeutic genome editing: prospects and challenges Advances in sickle cell therapies in the hydroxyurea era Erythro-megakaryocytic transcription factors associated with hereditary anemia Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway Corepressor Rcor1 is essential for murine erythropoiesis BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Perspectives in Genetics and Sickle Cell Disease Prevention in Africa: Beyond the Preliminary Data from Cameroon Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Treating sickle cell disease by targeting HbS polymerization Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression LIN28A expression reduces sickling of cultured human erythrocytes.Characterization of transcription factor networks involved in umbilical cord blood CD34+ stem cells-derived erythropoiesis.Gene therapy for hemoglobinopathies: the state of the field and the future.Genetics of human cardiovascular disease Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9 Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.Nuclease-mediated gene editing by homologous recombination of the human globin locus.BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells 2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment

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Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

http://www.wikidata.org/entity/Q37102932

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 13 October 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Correction of sickle cell dise ...... ith fetal hemoglobin silencing

@en

Correction of sickle cell dise ...... th fetal hemoglobin silencing.

@nl

type

label

Correction of sickle cell dise ...... ith fetal hemoglobin silencing

@en

Correction of sickle cell dise ...... th fetal hemoglobin silencing.

@nl

prefLabel

Correction of sickle cell dise ...... ith fetal hemoglobin silencing

@en

Correction of sickle cell dise ...... th fetal hemoglobin silencing.

@nl

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SCIENCE.1211053

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Correction of sickle cell dise ...... ith fetal hemoglobin silencing

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Benjamin L Ebert

http://www.w3.org/2001/XMLSchema#string

Bryan G Chong

http://www.w3.org/2001/XMLSchema#string

Cong Peng

http://www.w3.org/2001/XMLSchema#string

Erica B Esrick

http://www.w3.org/2001/XMLSchema#string

Jian Xu

http://www.w3.org/2001/XMLSchema#string

Philip W Tucker

http://www.w3.org/2001/XMLSchema#string

Stuart H Orkin

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Vijay G Sankaran

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Yuko Fujiwara

http://www.w3.org/2001/XMLSchema#string

P2860

Direct inhibition of the NOTCH transcription factor complex

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Developmental and species-divergent globin switching are driven by BCL11A

Bcl11a is essential for normal lymphoid development

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin.

Correction of sickle cell disease in transgenic mouse models by gene therapy.

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993-996

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scholarly article

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10.1126/SCIENCE.1211053

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6058

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334

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Gregory C Ippolito

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2011-10-13T00:00:00Z

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51716204

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21998251

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sickle-cell disease

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3746545

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