Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
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Visualizing functional motions of membrane transporters with molecular dynamics simulationsPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling.Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueMolecular Basis of Kainate Receptor Modulation by SodiumNa+ binding to meizothrombin desF1Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA poreStructures of a Na+-coupled, substrate-bound MATE multidrug transporterA Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E. coli Phosphofructokinase-2Elucidating factors important for monovalent cation selectivity in enzymes: E. coli β-galactosidase as a modelHow cations change peptide structure.Metal Ion Modeling Using Classical MechanicsConformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Selective complexation of K+ and Na+ in simple polarizable ion-ligating systemsTwo mechanisms of ion selectivity in protein binding sitesInsights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Ion conduction and conformational flexibility of a bacterial voltage-gated sodium channel.Simulations of anionic lipid membranes: development of interaction-specific ion parameters and validation using NMR data.Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.A selectivity filter at the intracellular end of the acid-sensing ion channel pore.The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.Exploring the ion selectivity properties of a large number of simplified binding site models.Statistical determinants of selective ionic complexation: ions in solvent, transport proteins, and other "hosts".Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.Single-molecule dynamics of gating in a neurotransmitter transporter homologueThe second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysisSelectivity of externally facing ion-binding sites in the Na/K pump to alkali metals and organic cationsMultibody effects in ion binding and selectivityConformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanismsMapping the importance of four factors in creating monovalent ion selectivity in biological molecules.An entropic mechanism of generating selective ion binding in macromolecules.Ion selectivity in channels and transportersThe role and specificity of the catalytic and regulatory cation-binding sites of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae.Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium SymportersCurrent and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.Simulating the distance distribution between spin-labels attached to proteins
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P2860
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
@en
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms.
@nl
type
label
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
@en
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms.
@nl
prefLabel
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
@en
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms.
@nl
P2860
P1476
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
@en
P2093
Benoît Roux
P2860
P304
P356
10.1016/J.JMB.2008.01.015
P407
P577
2008-01-15T00:00:00Z