Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.
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Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Docking screens: right for the right reasons?Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Targeting protein tyrosine phosphatases for anticancer drug discovery.Automated selection of compounds with physicochemical properties to maximize bioavailability and druglikeness.Molecular targets for the treatment of juvenile myelomonocytic leukemia.Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRafRole of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase functionDesign, synthesis, biological activity and molecular dynamics studies of specific protein tyrosine phosphatase 1B inhibitors over SHP-2Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignanciesComputational evaluation of protein-small molecule binding.Docking and chemoinformatic screens for new ligands and targets.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery.Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors.Targeting SHP2 phosphatase in myeloproliferative neoplasms.Protein tyrosine phosphatases in cardiac physiology and pathophysiology.
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P2860
Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of small molecu ...... bined with experimental assay.
@en
Identification of small molecu ...... taining tyrosine phosphatase 2
@nl
type
label
Identification of small molecu ...... bined with experimental assay.
@en
Identification of small molecu ...... taining tyrosine phosphatase 2
@nl
prefLabel
Identification of small molecu ...... bined with experimental assay.
@en
Identification of small molecu ...... taining tyrosine phosphatase 2
@nl
P2093
P2860
P356
P1476
Identification of small molecu ...... bined with experimental assay.
@en
P2093
Alexander D Mackerell
Cheng-Kui Qu
Olgun Guvench
Wen-Mei Yu
P2860
P304
P356
10.1021/JM800229D
P407
P577
2008-12-01T00:00:00Z