Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
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Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouseDevelopment of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate CancerIdentification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug designStructural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseHuman aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbonsSynthesis of (13)C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyreneThe Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-QuinonesContributions of human enzymes in carcinogen metabolismAldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment.Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10)Antioxidant-rich leaf extract of Barringtonia racemosa significantly alters the in vitro expression of genes encoding enzymes that are involved in methylglyoxal degradation IIIAldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels.Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.Emerging roles for retinoids in regeneration and differentiation in normal and disease statesEpidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells.Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis.AKR1B10 overexpression in breast cancer: association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker.Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds.Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant CancersAldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway.Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents.Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma.Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis.
P2860
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P2860
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
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name
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@en
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@nl
type
label
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@en
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@nl
prefLabel
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@en
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
@nl
P2860
P356
P1476
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10
@en
P2093
Amy M Quinn
Ronald G Harvey
P2860
P304
P356
10.1021/TX8002005
P577
2008-11-01T00:00:00Z