Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease. - Wikidata - awgldk - TriplyDB

Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.

Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.

http://www.wikidata.org/entity/Q37108151

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Gene expression profiling in cells with enhanced gamma-secretase activity.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer.Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.

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Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.

http://www.wikidata.org/entity/Q37108151

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2007

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Structural and Functional Dete ...... icated in Alzheimer's Disease.

@en

Structural and Functional Dete ...... icated in Alzheimer's Disease.

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type

label

Structural and Functional Dete ...... icated in Alzheimer's Disease.

@en

Structural and Functional Dete ...... icated in Alzheimer's Disease.

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prefLabel

Structural and Functional Dete ...... icated in Alzheimer's Disease.

@en

Structural and Functional Dete ...... icated in Alzheimer's Disease.

@nl

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138920207783769521

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Current Genomics

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Structural and Functional Dete ...... icated in Alzheimer's Disease.

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P2860

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

Purification and characterization of the human gamma-secretase complex

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.

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531-549

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scholarly article

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10.2174/138920207783769521

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8

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Patrick C Fraering

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2007-12-01T00:00:00Z

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24401435

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19415127

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Alzheimer's disease

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2647162

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