Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS
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Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor TherapeuticReduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner.Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo.[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling.Repurposing Tecfidera for cancer.Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model.Development and validation of a novel clinical fluorescence in situ hybridization assay to detect JAK2 and PD-L1 amplification: a fluorescence in situ hybridization assay for JAK2 and PD-L1 amplification.Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor‑positive, human epidermal growth factor receptor 2‑positive breast cancer cells.Targeting PDK4 inhibits breast cancer metabolism
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P2860
Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 March 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ruxolitinib synergizes with DM ...... ed SOD2/TRX expression and ROS
@en
Ruxolitinib synergizes with DM ...... d SOD2/TRX expression and ROS.
@nl
type
label
Ruxolitinib synergizes with DM ...... ed SOD2/TRX expression and ROS
@en
Ruxolitinib synergizes with DM ...... d SOD2/TRX expression and ROS.
@nl
prefLabel
Ruxolitinib synergizes with DM ...... ed SOD2/TRX expression and ROS
@en
Ruxolitinib synergizes with DM ...... d SOD2/TRX expression and ROS.
@nl
P2093
P2860
P356
P1433
P1476
Ruxolitinib synergizes with DM ...... ed SOD2/TRX expression and ROS
@en
P2093
Andrew Poklepovic
Jane L Roberts
Laurence Booth
Mehrad Tavallai
William P McGuire
P2860
P304
17290-17300
P356
10.18632/ONCOTARGET.8039
P407
P50
P577
2016-03-12T00:00:00Z