Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
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Gene therapy for severe combined immunodeficiency: are we there yet?Mechanisms and consequences of somatic mosaicism in humansRevertant mosaicism in skin: natural gene therapyFOXP3+ Tregs require WASP to restrain Th2-mediated food allergyAnalysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome.Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome.Intermittent X-linked thrombocytopenia with a novel WAS gene mutation.Wiskott-Aldrich syndrome/X-linked thrombocytopenia in China: Clinical characteristic and genotype-phenotype correlation.Gene transfer into hematopoietic stem cells as treatment for primary immunodeficiency diseases.Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.WASp in immune-system organization and function.Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings.In vivo reversion to normal of inherited mutations in humans.Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.Mosaicism of NK cells in a patient with Wiskott-Aldrich syndromeImpaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.Severe combined immunodeficiency. A model disease for molecular immunology and therapy.Basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites.Survival of the fittest: in vivo selection and stem cell gene therapyReversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1)Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome.Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome.Revertant mosaicism in genodermatoses.Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions.Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences.A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cellsOutcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning.Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease.Functional correction of T cells derived from patients with the Wiskott-Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS protein.Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome.Early deficit of lymphocytes in Wiskott-Aldrich syndrome: possible role of WASP in human lymphocyte maturation.A "late-but-fitter revertant cell" explains the high frequency of revertant mosaicism in epidermolysis bullosa.Decreased expression in nuclear factor-κB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency.Gene therapy of severe combined immunodeficienciesDevelopment of lentiviral gene therapy for Wiskott Aldrich syndrome
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Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 July 2001
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
@en
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
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type
label
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
@en
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
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prefLabel
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
@en
Somatic mosaicism in Wiskott-- ...... n by a DNA slippage mechanism.
@nl
P2093
P2860
P356
P1476
Somatic mosaicism in Wiskott-- ...... on by a DNA slippage mechanism
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P2093
P2860
P304
P356
10.1073/PNAS.151260498
P407
P577
2001-07-10T00:00:00Z