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Interleukin-32 promotes osteoclast differentiation but not osteoclast activationPEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cellsMAPKs in development: insights from Dictyostelium signaling pathwaysSelectivity of docking sites in MAPK kinasesStructural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein librariesuPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cellsComputational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factorsIntraocular expression and release of high-mobility group box 1 protein in retinal detachmentDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.Utilizing ras signaling pathway to direct selective replication of herpes simplex virus-1.shRNA interference for extracellular signal-regulated kinase 2 can inhibit the growth of esophageal cancer cell line Eca109.Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.Growth arrest signaling of the Raf/MEK/ERK pathway in cancer.Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase.Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ.Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors.Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifsDual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functionsBiochemical fluctuations, optimisation and the linear noise approximationKSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.Branched motifs enable long-range interactions in signaling networks through retrograde propagationPhysical Activity in the Prevention and Therapy of Breast Cancer.Sensitivity analysis predicts that the ERK-pMEK interaction regulates ERK nuclear translocation.A mammalian transcription factor-specific peptide repository for targeted proteomics.A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats.Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury.Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced PhenotypesERK1/2 can feedback-regulate cellular MEK1/2 levels.A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.Brucella abortus invasion of osteoblasts inhibits bone formation.Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms.CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms.Arl13b and the exocyst interact synergistically in ciliogenesisPigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia.Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The roles of MAPKs in disease.
@en
The roles of MAPKs in disease.
@nl
type
label
The roles of MAPKs in disease.
@en
The roles of MAPKs in disease.
@nl
prefLabel
The roles of MAPKs in disease.
@en
The roles of MAPKs in disease.
@nl
P2093
P2860
P356
P1433
P1476
The roles of MAPKs in disease.
@en
P2093
Arif Jivan
Chunli Shao
Daryl Goad
Elma Zaganjor
Jihan Osborne
Kathleen McGlynn
Lingling Duan
Melanie H Cobb
Michael C Lawrence
Steve Stippec
P2860
P2888
P304
P356
10.1038/CR.2008.37
P577
2008-04-01T00:00:00Z
P5875
P6179
1021883930