PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.
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Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDProtein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionOn the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesRecognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domainRegulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with themDeath effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIICMultiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic functionTumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cellsOmi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15Negative regulators of insulin signaling revealed in a genome-wide functional screenOverlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVRPEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastomaDeletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Discovery of small peptide antagonists of PED/PEA15-D4α interaction from simplified combinatorial libraries.DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.ERK2 enters the nucleus by a carrier-independent mechanismOverexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionIdentification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes.Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylationSystematic profiling of mRNA and miRNA expression in the pancreatic islets of spontaneously diabetic Goto-Kakizaki ratsPED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismExpression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle.A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismMitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer.PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiationEffect of SNPs in protein kinase C zeta gene on gene expression in the reporter gene detection systemAbsence of caspase 8 and high expression of PED protect primitive neural cells from cell death.Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1The roles of MAPKs in disease.Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL.Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells.
P2860
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P2860
PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
PED/PEA-15 gene controls gluco ...... ed in type 2 diabetes mellitus
@nl
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@ast
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en-gb
type
label
PED/PEA-15 gene controls gluco ...... ed in type 2 diabetes mellitus
@nl
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@ast
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en-gb
prefLabel
PED/PEA-15 gene controls gluco ...... ed in type 2 diabetes mellitus
@nl
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@ast
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en-gb
P2093
P2860
P921
P3181
P356
P1433
P1476
PED/PEA-15 gene controls gluco ...... d in type 2 diabetes mellitus.
@en
P2093
C Iavarone
F Andreozzi
F Beguinot
G Condorelli
G Vigliotta
L Beguinot
P Formisano
P2860
P304
P3181
P356
10.1093/EMBOJ/17.14.3858
P407
P577
1998-07-01T00:00:00Z