The role of calcium-activated protease calpain in experimental retinal pathology.
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Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degenerationCalpain activation in experimental glaucoma.N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 geneCalpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness.Using evolutionary conserved modules in gene networks as a strategy to leverage high throughput gene expression queriesEffects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant ratsPatient selection criteria for pilot studies on amelioration of non-neovascular age-related macular degeneration.Intravitreal injection of forskolin, homotaurine, and L-carnosine affords neuroprotection to retinal ganglion cells following retinal ischemic injuryStructural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachmentCalpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells.Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus modelCAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse modelCaspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell deathHypoxia Activates Calpains in the Nerve Fiber Layer of Monkey Retinal Explants.Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses.Mechanisms of retinal ganglion cell injury and defense in glaucoma.Calpain inhibitors: a survey of compounds reported in the patent and scientific literature.Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosisSmall-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion.Degeneration and dysfunction of retinal neurons in acute ocular hypertensive rats: involvement of calpains.Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells.Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.Calpain protease causes hypoxia-induced proteolysis in cultured human retina.Calpain-5 gene expression in the mouse eye and brain.
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The role of calcium-activated protease calpain in experimental retinal pathology.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The role of calcium-activated protease calpain in experimental retinal pathology.
@en
The role of calcium-activated protease calpain in experimental retinal pathology.
@nl
type
label
The role of calcium-activated protease calpain in experimental retinal pathology.
@en
The role of calcium-activated protease calpain in experimental retinal pathology.
@nl
prefLabel
The role of calcium-activated protease calpain in experimental retinal pathology.
@en
The role of calcium-activated protease calpain in experimental retinal pathology.
@nl
P2860
P1476
The role of calcium-activated protease calpain in experimental retinal pathology.
@en
P2093
P2860
P304
P356
10.1016/J.SURVOPHTHAL.2007.12.006
P577
2008-03-01T00:00:00Z