Proapoptotic effects of tau cleavage product generated by caspase-3.
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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's diseaseThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostTau clearance mechanisms and their possible role in the pathogenesis of Alzheimer diseaseLysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoTau Biology and Tau-Directed Therapies for Alzheimer's DiseaseFLASH coordinates NF-kappa B activity via TRAF2Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivoCalpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death.Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathologyIntracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53.Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain.The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer diseaseA caspase cleaved form of tau is preferentially degraded through the autophagy pathway.Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease.The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.Truncated tau and Aβ cooperatively impair mitochondria in primary neurons.Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.Are tangles as toxic as they look?The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsCaspase-mediated degeneration in Alzheimer's diseaseCaspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.The role of caspase cleavage of tau in Alzheimer disease neuropathology.Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?Characterization of TauC3 antibody and demonstration of its potential to block tau propagationAccumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.The role of calcium-activated protease calpain in experimental retinal pathology.The role of tau in neurodegenerationCaspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer diseaseA rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathyApoptosis and in vitro Alzheimer disease neuronal models.Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
P2860
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P2860
Proapoptotic effects of tau cleavage product generated by caspase-3.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Proapoptotic effects of tau cleavage product generated by caspase-3.
@ast
Proapoptotic effects of tau cleavage product generated by caspase-3.
@en
type
label
Proapoptotic effects of tau cleavage product generated by caspase-3.
@ast
Proapoptotic effects of tau cleavage product generated by caspase-3.
@en
prefLabel
Proapoptotic effects of tau cleavage product generated by caspase-3.
@ast
Proapoptotic effects of tau cleavage product generated by caspase-3.
@en
P2093
P356
P1476
Proapoptotic effects of tau cleavage product generated by caspase-3
@en
P2093
Mook-Jung IH
P304
P356
10.1006/NBDI.2000.0335
P577
2001-02-01T00:00:00Z