Long-term safety of dichloroacetate in congenital lactic acidosis. - Wikidata - awgldk - TriplyDB

Long-term safety of dichloroacetate in congenital lactic acidosis.

Long-term safety of dichloroacetate in congenital lactic acidosis.

http://www.wikidata.org/entity/Q37115699

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Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series)Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock.Treatment of mitochondrial disorders.Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Potential compounds for the treatment of mitochondrial disease.E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway.Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.Metabolic modulation of cancer: a new frontier with great translational potential.Treatment options for lactic acidosis and metabolic crisis in children with mitochondrial disease.Pharmacogenetic considerations with dichloroacetate dosing.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Metabolic support for the heart: complementary therapy for heart failure?A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.Therapies for mitochondrial diseases and current clinical trials.Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis.Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.Pyruvate dehydrogenase kinase 2 and 4 gene deficiency attenuates nociceptive behaviors in a mouse model of acute inflammatory pain.A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents.

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Long-term safety of dichloroacetate in congenital lactic acidosis.

http://www.wikidata.org/entity/Q37115699

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 April 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Long-term safety of dichloroacetate in congenital lactic acidosis.

@en

Long-term safety of dichloroacetate in congenital lactic acidosis.

@nl

type

label

Long-term safety of dichloroacetate in congenital lactic acidosis.

@en

Long-term safety of dichloroacetate in congenital lactic acidosis.

@nl

prefLabel

Long-term safety of dichloroacetate in congenital lactic acidosis.

@en

Long-term safety of dichloroacetate in congenital lactic acidosis.

@nl

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J.YMGME.2013.03.019

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Molecular Genetics and Metabolism

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Long-term safety of dichloroacetate in congenital lactic acidosis.

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Albert L Shroads

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Alicia Lew

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Bonnie S Coats

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Meena N Shankar

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Monica Abdelmalak

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Peter W Stacpoole

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Richard E Neiberger

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Ryan Ramezani

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S H Subramony

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Taimour Langaee

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P2860

A New Statistical Method for Haplotype Reconstruction from Population Data

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

Polymorphisms in the human glutathione transferase zeta promoter

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

Treatment of congenital lactic acidosis with dichloroacetate.

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

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139-143

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10.1016/J.YMGME.2013.03.019

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2

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2013-04-06T00:00:00Z

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dichloroacetate

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3751427

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