Treatment of congenital lactic acidosis with dichloroacetate.
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Role of dichloroacetate in the treatment of genetic mitochondrial diseasesClinical pharmacology and toxicology of dichloroacetateLow-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding PocketCombination of sulindac and dichloroacetate kills cancer cells via oxidative damageAn animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1αPopulation kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivoWhy are there no proven therapies for genetic mitochondrial diseases?Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetateReview of clinical trials for mitochondrial disorders: 1997-2012.Beneficial effect of feeding a ketogenic diet to mothers on brain development in their progeny with a murine model of pyruvate dehydrogenase complex deficiency.Long-term safety of dichloroacetate in congenital lactic acidosis.Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetateDevelopment of pharmacological strategies for mitochondrial disorders.The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Case report: Sodium dichloroacetate (DCA) inhibition of the "Warburg Effect" in a human cancer patient: complete response in non-Hodgkin's lymphoma after disease progression with rituximab-CHOP.Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.Development of a less toxic dichloroacetate analogue by docking and descriptor analysisDichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.Continuous pH monitoring using the Paratrend 7 inserted into a peripheral vein in a patient with shock and congenital lactic acidosis.The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.Dichloroacetate and cerebral ischaemia therapeutics.Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis.Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation.Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells
P2860
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P2860
Treatment of congenital lactic acidosis with dichloroacetate.
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Treatment of congenital lactic acidosis with dichloroacetate.
@ast
Treatment of congenital lactic acidosis with dichloroacetate.
@en
type
label
Treatment of congenital lactic acidosis with dichloroacetate.
@ast
Treatment of congenital lactic acidosis with dichloroacetate.
@en
prefLabel
Treatment of congenital lactic acidosis with dichloroacetate.
@ast
Treatment of congenital lactic acidosis with dichloroacetate.
@en
P2093
P2860
P356
P1476
Treatment of congenital lactic acidosis with dichloroacetate.
@en
P2093
C L Barnes
M D Hurbanis
P W Stacpoole
S L Cannon
P2860
P304
P356
10.1136/ADC.77.6.535
P407
P577
1997-12-01T00:00:00Z