A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells
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Smoking, p53 mutation, and lung cancerEffects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cellsKhz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen speciesExpression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesionsMolecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout miceFurin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cellsLoss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistanceWnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase CA five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.The p53 network in lung carcinogenesis.Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oIKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro.Increased furin activity enhances the malignant phenotype of human head and neck cancer cellsE-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells.Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators.Cigarette Smoking Condensate Disrupts Endoplasmic Reticulum-Golgi Network Homeostasis Through GOLPH3 Expression in Normal Lung Epithelial Cells.E2F8 as a Novel Therapeutic Target for Lung CancerValidation of a novel statistical model for assessing the synergy of combined-agent cancer chemoprevention.Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure.Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitorsN-7-Alkyl-2'-Deoxyguanosine as surrogate biomarkers for N-nitrosamine exposure in human lung.Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model.Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development.Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers.The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors.Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathwayPanaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species.Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans.Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT.Malignant transformation of HPV 16-immortalized human endocervical cells by cigarette smoke condensate and characterization of multistage carcinogenesis.The tar fraction of cigarette smoke does not promote arteriosclerotic plaque development.Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
P2860
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P2860
A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A tobacco-specific N-nitrosami ...... man bronchial epithelial cells
@en
A tobacco-specific N-nitrosami ...... an bronchial epithelial cells.
@nl
type
label
A tobacco-specific N-nitrosami ...... man bronchial epithelial cells
@en
A tobacco-specific N-nitrosami ...... an bronchial epithelial cells.
@nl
prefLabel
A tobacco-specific N-nitrosami ...... man bronchial epithelial cells
@en
A tobacco-specific N-nitrosami ...... an bronchial epithelial cells.
@nl
P2093
P2860
P356
P1476
A tobacco-specific N-nitrosami ...... man bronchial epithelial cells
@en
P2093
A J Klein-Szanto
C C Harris
I Garcia-Palazzo
P2860
P304
P356
10.1073/PNAS.89.15.6693
P407
P577
1992-08-01T00:00:00Z