Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
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Ubc13: the Lys63 ubiquitin chain building machineThe TLR and IL-1 signalling network at a glancePellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferonsPellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitisThe WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signatureRoles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.Profile of Phillip Cohen.Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1betaMyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.Functional conservation of an ancestral Pellino protein in helminth speciesPellino-1 selectively regulates epithelial cell responses to rhinovirus.Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional controlE2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells.Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance.New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis.The roles of Pellino E3 ubiquitin ligases in immunity.Immune diseases caused by mutations in kinases and components of the ubiquitin system.Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses.Phosphorylation of receptor-like cytoplasmic kinases by bacterial flagellin.The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways.A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling.DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3Pellino1 is required for interferon production by viral double-stranded RNA.Keep nibbling at the edges.Profile of Philip Cohen. Interview by Carrie Arnold.The family of the interleukin-1 receptors.Crystal structure of human IRAK1.The role of TBK1 and IKKε in the expression and activation of Pellino 1.IRAK1 phosphorylates PellinoIRAK1 phosphorylates Pellino upon TLR7/8 or 9 activationhp-IRAK1; hp-IRAK4 4 phosphorylate Pellino-1 and 2.Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome.
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Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@en
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@nl
type
label
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@en
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@nl
prefLabel
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@en
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@nl
P2093
P2860
P356
P1476
Identification of the phosphor ...... activation by IRAK1 and IRAK4.
@en
P2093
David G Campbell
Emma Carrick
Franck Vandermoere
Hilary Smith
Mark Peggie
Philip Cohen
P2860
P304
P356
10.1073/PNAS.0900774106
P407
P577
2009-03-05T00:00:00Z