Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri
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An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitorsAnalysis of enzyme kinetic data for mtDNA replication.Structural basis for the D-stereoselectivity of human DNA polymerase β.Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infantsA mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseasemip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiaeAnti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitroStructural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerasePharmacological considerations for tenofovir and emtricitabine to prevent HIV infectionPre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.Tenofovir disoproxil fumarate for the treatment of HIV infection.A cell-based strategy to assess intrinsic inhibition efficiencies of HIV-1 reverse transcriptase inhibitors.Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.Presteady state kinetic investigation of the incorporation of anti-hepatitis B nucleotide analogues catalyzed by noncanonical human DNA polymerasesProbing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γEnantioselectivity of human AMP, dTMP and UMP-CMP kinases.Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicaseBalancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase.Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase.Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol.Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all?Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture.Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Structural insight on processivity, human disease and antiviral drug toxicity.Clinical features of adverse reactions associated with telbivudine.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine.Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
P2860
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P2860
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Relationship between antiviral ...... criptase and human mitochondri
@en
Relationship between antiviral ...... criptase and human mitochondri
@nl
type
label
Relationship between antiviral ...... criptase and human mitochondri
@en
Relationship between antiviral ...... criptase and human mitochondri
@nl
prefLabel
Relationship between antiviral ...... criptase and human mitochondri
@en
Relationship between antiviral ...... criptase and human mitochondri
@nl
P2093
P2860
P1476
Relationship between antiviral ...... criptase and human mitochondri
@en
P2093
Allison A Johnson
Eisuke Murakami
Joy Y Feng
Karen S Anderson
Kenneth A Johnson
Phillip A Furman
Suzana M Zorca
P2860
P304
P356
10.1128/AAC.48.4.1300-1306.2004
P407
P577
2004-04-01T00:00:00Z