Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes
about
sameAs
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinaseMolecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinaseSelective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosineMechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidineInhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogsCharacterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosidesPharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2'R,5'S-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, an agent active against human immunodeficiency virus and human hepatitis B virusAnti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitroNew classes of fluorinated L-nucleosides; synthesis and antiviral activityHomologues of isomeric dideoxynucleosides as potential antiviral agents: synthesis of isodideoxynucleosides with a furanethanol sugar moietyGeneration of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidineThe same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidineIncreased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyureaSynthesis and antiviral activity of aryl phosphoramidate derivatives of beta-D- and beta-L-C-5-substituted 2',3'-didehydro-2',3'-dideoxy-uridine bearing linker arms.Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeysMolecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agentsAntiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionPharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with renal dysfunction.Antiviral therapy for human immunodeficiency virus infectionsProbing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.Preferential incorporation of nucleoside analogs after template switching during human immunodeficiency virus reverse transcriptionEffects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNAInfectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase.Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosidesExonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase.Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondriEfficacies of beta-L-D4A against Hepatitis B virus in 2.2.15 cells.The genetic toxicity effects of lamivudine and stavudine antiretroviral agents.Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).Synthesis of novel L-N-MCd4T as a potent anti-HIV agent.Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.Synthesis and antiviral activity of fluoro-substituted apio dideoxynucleosides.
P2860
Q24670452-FC644D10-9392-457A-8A49-00A3DB37647DQ27650566-35DAFCD6-F054-43F8-A93F-EE5C1119FC48Q28342752-D1D65A87-6DC4-4176-9C26-7EA788706C88Q28367438-1BF830D3-D038-42E3-9E4A-D95599DB11FAQ28367642-7F7B24C1-234E-4691-AF03-842156561744Q28368026-38091984-E262-4A6E-B022-10CEB73DC0D3Q28368057-46BC7A96-4107-4B1B-9359-94657B4A7E94Q28369464-2FE2DFCB-2159-43D7-B389-9D7D17C2F938Q28369966-578BF3A4-A676-46B2-A954-F1B7277CEC66Q28375823-9CF30301-04B5-4370-B5A3-14B255840B96Q28378611-B3C0D16B-7128-4EE7-AD69-020812680F1DQ28378626-D34AE43C-D337-4783-A5B5-1CE8B1B568CEQ28379471-0228353B-A33F-49F3-B146-1DC8C610E978Q33231478-9B8777A8-C608-4AB6-9CB5-F14C4BF2334EQ33745246-665CBF5F-590E-4BE9-AB86-943B533B67B1Q33804880-F7EF7779-2379-483C-871C-977493FADCFAQ33976709-44914D35-3996-4C94-BD0F-698E3AC90A32Q33981149-D880F557-FE24-4054-88A3-CEDAF78705FFQ35013945-6CC3DD92-7632-461F-953C-7294168D8D92Q35114114-738240A6-6D60-4E1B-A61F-CBCC37306743Q35122784-1A8615AE-4012-4D02-BF06-A8806E72233DQ35125144-4FF4CCA7-BD22-4266-B981-1E2607B7C7A0Q35366050-6DC06182-F8A7-4C52-9B9B-F54025B87141Q35548123-5D5C7E82-22C1-4EF7-B8AF-05959934DE84Q35820362-2973EE9B-3A0B-48BE-BDD6-FF9C25AB3683Q35854248-8C9BCA6D-D51F-4775-97CD-EB00B00EB423Q35897545-C9496F67-7AD8-4D69-848C-DA4A2718EF61Q35905947-B1AB0D9F-CEF2-4666-B38A-755D7D3310E6Q36328820-DF002A31-7C67-4FD8-AE2F-DC16068B6A6BQ36374005-506D2F07-F211-4E4D-9F88-E6EFDAED1E79Q36422647-405DE710-7697-4BAA-B19F-580CE5D05E0FQ37120519-C1B9642B-01B2-4984-9338-736BBBFB2956Q37212962-544923B2-33A9-4143-B081-ECBFC3508C8DQ37727229-D69482CB-8AF7-4766-9FC3-834F5E5AD21FQ37734538-F5C03C1E-D06C-4EFA-8CDA-20834FD74C82Q37767303-BF36DD70-F7E0-4858-8747-637184AE5825Q38405371-E114BFDE-8080-4EC2-AF19-53CD60786C6EQ38506878-7D58FBDF-CE19-4530-A2BF-CD8A3459F897Q38511971-57E6173B-AA7F-41D4-83FE-3D98C823A01CQ38524900-881EB117-9F95-4E90-BA5D-60E16F7ED034
P2860
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Activities of the four optical ...... us type 1 in human lymphocytes
@ast
Activities of the four optical ...... us type 1 in human lymphocytes
@en
Activities of the four optical ...... us type 1 in human lymphocytes
@nl
type
label
Activities of the four optical ...... us type 1 in human lymphocytes
@ast
Activities of the four optical ...... us type 1 in human lymphocytes
@en
Activities of the four optical ...... us type 1 in human lymphocytes
@nl
prefLabel
Activities of the four optical ...... us type 1 in human lymphocytes
@ast
Activities of the four optical ...... us type 1 in human lymphocytes
@en
Activities of the four optical ...... us type 1 in human lymphocytes
@nl
P2093
P2860
P356
P1476
Activities of the four optical ...... us type 1 in human lymphocytes
@en
P2093
A McMillan
R F Schinazi
P2860
P356
10.1128/AAC.36.3.672
P407
P577
1992-03-01T00:00:00Z