Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.
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The balance of powers: Redox regulation of fibrogenic pathways in kidney injuryJanus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsSesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.Sestrins orchestrate cellular metabolism to attenuate aging.Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengueParticipation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.Upregulation of Sestrin2 expression protects against macrophage apoptosis induced by oxidized low-density lipoprotein.Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.Activation of AMP-activated protein kinase prevents TGF-β1-induced epithelial-mesenchymal transition and myofibroblast activation.Luminal flow induces NADPH oxidase 4 translocation to the nuclei of thick ascending limbsAMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury.Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.Diabetes and Kidney Disease: Role of Oxidative Stress.mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic diseaseNox and renal disease.Sex-specific eNOS activity and function in human endothelial cells.Biochemical Basis of Sestrin Physiological Activities.Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.The metabolic syndrome and chronic kidney disease.Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases.Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II.Statin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI.
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Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@en
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@nl
type
label
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@en
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@nl
prefLabel
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@en
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression.
@nl
P2093
P2860
P356
P1476
Sestrin 2 and AMPK connect hyp ...... and matrix protein expression
@en
P2093
Assaad A Eid
Doug-Yoon Lee
Khaled Khazim
Linda J Roman
P2860
P304
P356
10.1128/MCB.00217-13
P407
P50
P577
2013-07-01T00:00:00Z