Centrosome amplification can initiate tumorigenesis in flies.
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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerCep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosomeCep76, a centrosomal protein that specifically restrains centriole reduplicationBug22 influences cilium morphology and the post-translational modification of ciliary microtubulesMaintaining Genome Stability in Defiance of Mitotic DNA DamageKIFC1: a promising chemotherapy target for cancer treatment?Centrosomes, chromosome instability (CIN) and aneuploidyHeading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migrationInterphase centrosome organization by the PLP-Cnn scaffold is required for centrosome functionDissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivoLateral adhesion drives reintegration of misplaced cells into epithelial monolayersAneuploidy causes premature differentiation of neural and intestinal stem cellsA CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancerThe c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cellsCentrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegansMultipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cellsSmall-molecule kinase inhibitors provide insight into Mps1 cell cycle functionThe Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication FactorThe PLK4-STIL-SAS-6 module at the core of centriole duplicationThe more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancersMDM1 is a microtubule-binding protein that negatively regulates centriole duplicationAsymmetric cell division of stem and progenitor cells during homeostasis and cancerCDK5RAP2 regulates centriole engagement and cohesion in miceAcentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryoComparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebratesA mechanism linking extra centrosomes to chromosomal instabilityControl of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering.Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase.The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cellsCP110 exhibits novel regulatory activities during centriole assembly in Drosophila.LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Oncogene-like induction of cellular invasion from centrosome amplification.YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplificationA genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.
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Centrosome amplification can initiate tumorigenesis in flies.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Centrosome amplification can initiate tumorigenesis in flies.
@en
Centrosome amplification can initiate tumorigenesis in flies.
@nl
type
label
Centrosome amplification can initiate tumorigenesis in flies.
@en
Centrosome amplification can initiate tumorigenesis in flies.
@nl
prefLabel
Centrosome amplification can initiate tumorigenesis in flies.
@en
Centrosome amplification can initiate tumorigenesis in flies.
@nl
P2093
P2860
P50
P1433
P1476
Centrosome amplification can initiate tumorigenesis in flies
@en
P2093
Alexey Khodjakov
Kathrin Brunk
Renata Basto
Tatiana Vinadogrova
P2860
P304
P356
10.1016/J.CELL.2008.05.039
P407
P577
2008-06-01T00:00:00Z