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The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cellsDissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivoMaintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin.Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRCCP110 exhibits novel regulatory activities during centriole assembly in Drosophila.A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.Drosophila Ana2 is a conserved centriole duplication factorHsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.Drosophila Spd-2 recruits PCM to the sperm centriole, but is dispensable for centriole duplication.Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.Drosophila Ana1 is required for centrosome assembly and centriole elongation.Centrosome amplification can initiate tumorigenesis in flies.Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies.Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.The Drosophila GAGA transcription factor is associated with specific regions of heterochromatin throughout the cell cycleAsterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.Structural Basis for Mitotic Centrosome Assembly in Flies.Happy 5th Birthday Biology Open.The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics.DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement.Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis.The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time.Mitosis in motion.Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.A homeostatic clock sets daughter centriole size in flies.Lessons learned: eight years at the helm of Biology OpenA positive feedback loop drives centrosome maturation in fliesDrosophila PLP forms centriolar-clouds that promote centriole stability, cohesion and MT nucleationEvidence that a positive feedback loop drives centrosome maturation in fly embryosSas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole/centrosome assembly
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Jordan W Raff
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Jordan W Raff
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Jordan W Raff
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Jordan W Raff
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Jordan W Raff
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type
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Jordan W Raff
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Jordan W Raff
@en
Jordan W Raff
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Jordan W Raff
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Jordan W Raff
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prefLabel
Jordan W Raff
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Jordan W Raff
@en
Jordan W Raff
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Jordan W Raff
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Jordan W Raff
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P106
P21
P31
P496
0000-0002-4689-1297