Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41
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Broad Distribution of Energetically Important Contacts across an Extended Protein InterfaceStructure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework.Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor.NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41.Targeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapyDNA Triplex-Based Complexes Display Anti-HIV-1-Cell Fusion Activity.Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosisScreening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Peptides in the treatment of AIDS.HIV microbicides: state-of-the-art and new perspectives on the development of entry inhibitors.Amphipathic properties of HIV-1 gp41 fusion inhibitors.Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocketComputer-Aided Approaches for Targeting HIVgp41.Molecular dynamics modeling the synthetic and biological polymers interactions pre-studied via docking: anchors modified polyanions interference with the HIV-1 fusion mediatorStructure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41.Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015).Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41.Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting the gp41 pocket.Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41.Structure-based bioisosterism design, synthesis, insecticidal activity and structure-activity relationship (SAR) of anthranilic diamide analogues containing 1,2,4-oxadiazole rings.An effective conjugation strategy for designing short peptide-based HIV-1 fusion inhibitors.1-(3,5-Dimeth-oxy-benz-yl)-1H-pyrrole.A novel view of modelling interactions between synthetic and biological polymers via docking.A detective story in drug discovery: elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA polymerase.
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Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Design, synthesis, and biologi ...... sion inhibitors targeting gp41
@en
Design, synthesis, and biologi ...... ion inhibitors targeting gp41.
@nl
type
label
Design, synthesis, and biologi ...... sion inhibitors targeting gp41
@en
Design, synthesis, and biologi ...... ion inhibitors targeting gp41.
@nl
prefLabel
Design, synthesis, and biologi ...... sion inhibitors targeting gp41
@en
Design, synthesis, and biologi ...... ion inhibitors targeting gp41.
@nl
P2093
P2860
P50
P356
P1476
Design, synthesis, and biologi ...... sion inhibitors targeting gp41
@en
P2093
Bo-Tao Fan
Shuwen Liu
P2860
P304
P356
10.1021/JM800869T
P407
P577
2008-12-01T00:00:00Z