Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors.
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Minireview: the role of nuclear receptors in photoreceptor differentiation and diseaseThe Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed ConformationBiology and therapy of inherited retinal degenerative disease: insights from mouse modelsRetinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor developmentRegulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRLPotential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis PigmentosaPharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital AmaurosisStructure of cone photoreceptors.Distinct signature of altered homeostasis in aging rod photoreceptors: implications for retinal diseases.Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation.Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposurePhotoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina.Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysisHybrid mice reveal parent-of-origin and Cis- and trans-regulatory effects in the retinaDifferent effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration miceEnRICH: Extraction and Ranking using Integration and Criteria HeuristicsFeedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndromeA CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degenerationCharacterization of the pituitary tumor transforming gene 1 knockout mouse retina.Mouse retinal development: a dark horse model for systems biology researchIL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis.The transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative promoter.Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursorsTranscriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinantVision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and diseaseSelective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration.Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina developmentTranscriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene NetworksPreservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retinaInactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesisWhole exome sequencing identifies a novel NRL mutation in a Chinese family with autosomal dominant retinitis pigmentosa.cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindnessNr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransductionIdentification of the Photoreceptor Transcriptional Co-Repressor SAMD11 as Novel Cause of Autosomal Recessive Retinitis PigmentosaA comprehensive analysis of sequence variants and putative disease-causing mutations in photoreceptor-specific nuclear receptor NR2E3.
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Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@en
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@nl
type
label
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@en
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@nl
prefLabel
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@en
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@nl
P2093
P2860
P1433
P1476
Rod differentiation factor NRL ...... opment of cone photoreceptors.
@en
P2093
Edwin C T Oh
Hong Cheng
Naheed Wali Khan
P2860
P356
10.1016/J.BRAINRES.2008.01.028
P407
P577
2008-01-18T00:00:00Z