TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.
about
SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activityPodocytesCalcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapiesCell biology and pathology of podocytesCalcium regulates podocyte actin dynamics.NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complexNFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db miceGenetic testing in steroid-resistant nephrotic syndrome: when and how?Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease.TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.Single-channel analysis of TRPC channels in the podocytes of freshly isolated GlomeruliActivation of NFAT signaling in podocytes causes glomerulosclerosis.TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease.TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathyAngiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.Influence of tacrolimus on podocyte injury inducted by angiotensin II.Gq signaling causes glomerular injury by activating TRPC6.Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.Progress in pathogenesis of proteinuria.TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory responseMiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death.Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channelsLysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation.Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)Calcium-permeable ion channels in the kidney.TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways.The podocyte as a direct target for treatment of glomerular disease?Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis.Tyrosine kinase signaling in kidney glomerular podocytes.Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney.Balancing calcium signals through TRPC5 and TRPC6 in podocytes.Regulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis.Childhood nephrotic syndrome--current and future therapies.NFAT gene family in inflammation and cancer.Podocyte mitosis - a catastrophe.Familial FSGS.Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology.Pleiotropic signaling evoked by tumor necrosis factor in podocytes.
P2860
Q24304302-0C31A331-922A-4B61-A042-53F1BB0ED338Q26766118-3DABB78F-A77F-4A65-BEA3-81E29E7F6CF9Q26778579-FC84040B-6DC2-48B1-9988-7F77975F08F7Q26853664-60C41C66-B3C8-46D6-B912-6BDA84D22440Q27692627-7AD37B24-1518-4988-8732-287F647E3416Q28296660-4161F50A-9F9F-477E-B505-84829EB1B2F4Q28661524-AAFFB860-2A59-4113-89B6-4EA77E3B8574Q33361808-B4F312D0-66DA-46F1-B13B-205B54A72685Q33705025-88411937-F6A8-49DD-9D65-E5145080873AQ34211578-418E649C-1AB1-4312-B17A-B4502593E0E5Q34273590-149B5496-BCBB-43D4-92E8-7362003E550DQ34455455-DBD98B00-B800-4FD1-B00E-D44C61C22EF0Q34993566-86F7B4A4-5312-4781-AD45-1B9D5D7DD053Q35206224-25C73040-FB68-4259-8AD7-298C785B872AQ35235668-334C2F41-7657-42F3-89E4-919617AB98E9Q35554968-1B8C63C5-B17C-4159-8CEA-F85535BF77AFQ35719874-E4397B66-C1EC-4DD1-BA8E-79E86C8C37DEQ35780729-D13840C2-52E5-4C6C-91F5-EAC6B0EA72B4Q36011008-BC296C0D-4C64-44B0-8111-540F6086B83BQ36180644-59C79B60-F7EF-49C6-9D89-8BA0E0F6762DQ36247357-5EAC10DD-8AF7-4E7E-89F9-E2E24E52DEFBQ36294421-AAFC4A28-2D84-4A2D-BBA3-DD0998A27DD6Q36360722-03E61F52-009F-4E1A-8380-248FADF9FF69Q36610011-384419E9-CB9B-477E-8EC5-6286CBA6FE8FQ36947844-D5FE5F2F-84D2-437D-B986-3983CDC78632Q37072422-C633B3CD-67A4-4C10-98A7-7E6805060B00Q37072696-FE1D8ACA-5176-4512-87B3-2F970F463A56Q37139449-67F06AB1-7F89-45DC-AEEC-C7AAEB523822Q37405051-C694FB1C-D341-451F-8A00-94B2E024A2B9Q37886419-B670069C-5C77-4AF0-91AF-D45C99381A7BQ37903259-FD27BDE2-44B0-4754-9E27-4C2115E8BFE1Q37908184-F6A7C634-6A1A-403B-9F4E-C0DE6CE394BFQ37943290-FC6AFDE3-271C-4721-AFB3-FC40E650389FQ37960090-C40FA769-53ED-46E3-882F-CEF1B18A5312Q38017937-90937FF3-69BA-433D-90BE-56357D4097CEQ38040813-B6E03B21-4D08-449D-8D75-B1E286AC3948Q38061941-C363B149-18CC-4765-B24B-E1595DD1746BQ38244354-E118FA61-419A-49CF-A363-CECE6664A6C6Q38758929-B9153188-E3E0-4A93-A212-EA4F88C77562Q38870270-FA12179F-1392-4881-B768-3EB623375CA3
P2860
TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@en
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@nl
type
label
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@en
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@nl
prefLabel
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@en
TRPC6 mutations associated wit ...... NFAT-dependent transcription.
@nl
P2093
P2860
P1476
TRPC6 mutations associated wit ...... f NFAT-dependent transcription
@en
P2093
Donato Del Camino
Martin R Pollak
Robert Carrasquillo
Vanessa Lacey
P2860
P304
P356
10.1152/AJPCELL.00077.2008
P577
2009-01-07T00:00:00Z