Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy.
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Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics.The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release.Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activityFirst-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid TumorsTrop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC).Cancer therapies utilizing the camptothecins: a review of the in vivo literatureCEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates.Using antibodies to target cancer therapeutics.Challenges in SN38 drug delivery: current success and future directions.Sacituzumab govitecan: an antibody-drug conjugate.Injectable SN-38-loaded Polymeric Depots for Cancer Chemotherapy of Glioblastoma Multiforme.Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation.Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.Combination radioimmunotherapy and chemoimmunotherapy involving different or the same targets improves therapy of human pancreatic carcinoma xenograft models.Human serum albumin conjugates of 7-ethyl-10-hydroxycamptothecin (SN38) for cancer treatment.Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imagingPlacenta-specific1 (PLAC1) is a potential target for antibody-drug conjugate-based prostate cancer immunotherapy.The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates.The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target.
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P2860
Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antibody conjugates of 7-ethyl ...... targeted cancer chemotherapy.
@en
Antibody conjugates of 7-ethyl-10-hydroxycamptothecin
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type
label
Antibody conjugates of 7-ethyl ...... targeted cancer chemotherapy.
@en
Antibody conjugates of 7-ethyl-10-hydroxycamptothecin
@nl
prefLabel
Antibody conjugates of 7-ethyl ...... targeted cancer chemotherapy.
@en
Antibody conjugates of 7-ethyl-10-hydroxycamptothecin
@nl
P2093
P2860
P356
P1476
Antibody conjugates of 7-ethyl ...... targeted cancer chemotherapy.
@en
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Christopher A D'Souza
David M Goldenberg
Hans J Hansen
Serengulam V Govindan
Sung-Ju Moon
Thomas M Cardillo
P2860
P304
P356
10.1021/JM800719T
P407
P577
2008-10-22T00:00:00Z