Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs
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Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cellsMolecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich regionRegulation and localization of ribosomal protein S6 kinase 1 isoformsDual requirement for a newly identified phosphorylation site in p70s6kRegulation of B-Myb activity by cyclin D1Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alphaRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteIdentification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytesControl of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathwayAmino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanismInsulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize.Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities.Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.Structural and functional analysis of pp70S6k.Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancerDisruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo.cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylationThe modular phosphorylation and activation of p70s6k.Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioningExpression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1).Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase.p70 S6 kinase and actin dynamics: A perspective.Exploiting p70 S6 kinase as a target for ovarian cancer.Multiple independent inputs are required for activation of the p70 S6 kinase.Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in humaThe principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.S6 phosphorylation and the p70s6k/p85s6k.Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on August 1992
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs
@en
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs.
@nl
type
label
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs
@en
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs.
@nl
prefLabel
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs
@en
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs.
@nl
P2093
P2860
P356
P1476
Activation of p70s6k is associ ...... displaying Ser/Thr-Pro motifs
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.15.7282
P407
P577
1992-08-01T00:00:00Z