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Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cellsAntisense treatment directed against mutated Ki-ras in human colorectal adenocarcinomaInhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotidesMapping of RNA accessible sites by extension of random oligonucleotide libraries with reverse transcriptase.The use of antisense oligonucleotides in Xenopus oocytes.A short antisense oligonucleotide ameliorates symptoms of severe mouse models of spinal muscular atrophyAntisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury modelRegulation of apoptosis by fau revealed by functional expression cloning and antisense expression.Prioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsAntisense properties of duplex- and triplex-forming PNAs.Determination of interactions between structured nucleic acids by fluorescence resonance energy transfer (FRET): selection of target sites for functional nucleic acids.Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.Hydrolysis of bulged nucleotides in hybrids formed by RNA and imidazole-derivatized oligo-2'-O-methylribonucleotides.Design and specificity of hammerhead ribozymes against calretinin mRNA.Studies on the expression of sesquiterpene synthases using promoter-β-glucuronidase fusions in transgenic Artemisia annua LVariables and strategies in development of therapeutic post-transcriptional gene silencing agentsFunctional genomics and radioisotope-based imaging procedures.The H1A histone variant is an in vivo repressor of oocyte-type 5S gene transcription in Xenopus laevis embryos.Inhibition of proopiomelanocortin expression by an oligodeoxynucleotide complementary to beta-endorphin mRNA.Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs.Reexpression of glial fibrillary acidic protein rescues the ability of astrocytoma cells to form processes in response to neuronsUse of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistanceIn vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes.Detection of undegraded oligonucleotides in vivo by fluorescence resonance energy transfer. Nuclease activities in living sea urchin eggs.ISIS 301012 gene therapy for hypercholesterolemia: sense, antisense, or nonsense?Antisense oligodeoxynucleotides selectively suppress expression of the mutant alpha 2(I) collagen allele in type IV osteogenesis imperfecta fibroblasts. A molecular approach to therapeutics of dominant negative disorders.Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.Enhancement of selectivity in recognition of nucleic acids via chemical autoligation.Towards improved oligonucleotide therapeutics through faster target binding kinetics.Design, biochemical, biophysical and biological properties of cooperative antisense oligonucleotides.Sequence context of antisense RelA/NF-kappa B phosphorothioates determines specificity.Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo.Molecular recognition properties of IGS-mediated reactions catalyzed by a Pneumocystis carinii group I intron.Managing the sequence-specificity of antisense oligonucleotides in drug discovery.RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.Opening of the extraordinarily stable mini-hairpin d(GCGAAGC)RNA heptamers that direct RNA cleavage by mammalian tRNA 3' processing endoribonuclease.In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.Guide RNA requirement for editing-site-specific endonucleolytic cleavage of preedited mRNA by mitochondrial ribonucleoprotein particles in Trypanosoma brucei.Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Specificity of antisense oligonucleotides in vivo.
@en
Specificity of antisense oligonucleotides in vivo.
@nl
type
label
Specificity of antisense oligonucleotides in vivo.
@en
Specificity of antisense oligonucleotides in vivo.
@nl
prefLabel
Specificity of antisense oligonucleotides in vivo.
@en
Specificity of antisense oligonucleotides in vivo.
@nl
P2093
P2860
P356
P1476
Specificity of antisense oligonucleotides in vivo.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.16.7305
P407
P577
1992-08-01T00:00:00Z