Kinetic isotope effects in hydroxylation reactions effected by cytochrome P450 compounds I implicate multiple electrophilic oxidants for P450-catalyzed oxidations.
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Hydrocarbon hydroxylation by cytochrome P450 enzymesMechanisms of peroxynitrite interactions with heme proteinsQuantitative production of compound I from a cytochrome P450 enzyme at low temperatures. Kinetics, activation parameters, and kinetic isotope effects for oxidation of benzyl alcohol.Oxidation reactions performed by soluble methane monooxygenase hydroxylase intermediates H(peroxo) and Q proceed by distinct mechanismsReactive intermediates in cytochrome p450 catalysis.The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1).Kinetics and activation parameters for oxidations of styrene by Compounds I from the cytochrome P450(BM-3) (CYP102A1) heme domain and from CYP119.Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactions
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Kinetic isotope effects in hydroxylation reactions effected by cytochrome P450 compounds I implicate multiple electrophilic oxidants for P450-catalyzed oxidations.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@en
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
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type
label
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@en
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@nl
prefLabel
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@en
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@nl
P2093
P2860
P356
P1433
P1476
Kinetic isotope effects in hyd ...... for P450-catalyzed oxidations.
@en
P2093
Haoming Zhang
Martin Newcomb
Paul F Hollenberg
P2860
P304
P356
10.1021/BI802279D
P407
P577
2009-02-01T00:00:00Z