MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.
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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Early evolution without a tree of lifeSomatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors.Fluorescent duplex allele-specific PCR and amplicon melting for rapid homogeneous mtDNA haplogroup H screening and sensitive mixture detection.Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.Plastids, genomes, and the probability of gene transfer.Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing dataMitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.Functional recurrent mutations in the human mitochondrial phylogeny: dual roles in evolution and diseaseThe impact of darwinian evolution on medicine: the maternal side of the story.Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates.Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential.Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes.The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Deciphering the signature of selective constraints on cancerous mitochondrial genome.Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations.Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.The pattern of natural selection in somatic cancer mutations of human mtDNA.Accumulation of mutations over the entire mitochondrial genome of breast cancer cells obtained by tissue microdissection.
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MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MtDNA mutation pattern in tumo ...... similar selective constraints.
@en
MtDNA mutation pattern in tumo ...... similar selective constraints.
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MtDNA mutation pattern in tumo ...... similar selective constraints.
@en
MtDNA mutation pattern in tumo ...... similar selective constraints.
@nl
prefLabel
MtDNA mutation pattern in tumo ...... similar selective constraints.
@en
MtDNA mutation pattern in tumo ...... similar selective constraints.
@nl
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MtDNA mutation pattern in tumo ...... similar selective constraints
@en
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Eitan Rubin
Erez A Livneh
Ilia Zhidkov
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P304
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10.1101/GR.086462.108
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P577
2009-02-10T00:00:00Z