Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
about
Multidrug resistance in bacteriaEfflux-mediated drug resistance in bacteria: an updateRecent advances toward a molecular mechanism of efflux pump inhibitionFunctional rotation of the transporter AcrB: insights into drug extrusion from simulationsTransport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loopEvaluation of multidrug efflux pump inhibitors by a new method using microfluidic channelsDynamical Model of Drug Accumulation in Bacteria: Sensitivity Analysis and Experimentally Testable PredictionsMultidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimerβ-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket.Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli.Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2'-dinaphthylamine efflux assay.Structure and mechanism of RND-type multidrug efflux pumpsProperties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli.Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coliCoupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrBSubstrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB.Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitorsInteraction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosaImportance of Real-Time Assays To Distinguish Multidrug Efflux Pump-Inhibiting and Outer Membrane-Destabilizing Activities in Escherichia coli.Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.Risk factors for efflux pump overexpression in fluoroquinolone-resistant Escherichia coliMexXY multidrug efflux system of Pseudomonas aeruginosa.Programming stress-induced altruistic death in engineered bacteriaAminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pumpPermeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivativesPermeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channelsStructural and functional aspects of the multidrug efflux pump AcrB.Multicomponent drug efflux complexes: architecture and mechanism of assembly.Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.Molecular Dynamics Computer Simulations of Multidrug RND Efflux PumpsBroad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria.Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.Bifurcation kinetics of drug uptake by Gram-negative bacteria.
P2860
Q22255652-9F45B688-BA22-41D2-AF1C-00A67C241E0DQ24609407-22CFEC59-DD47-4052-9101-030B36F5483DQ27004685-1914A224-3911-4BFF-A503-04C95B72F58FQ27334906-8325FF82-E266-4C2E-9CF8-155341FBF7AAQ27678230-E42B09B9-2206-4A9D-8F69-FF9BFFC3DE1DQ28477724-4F9AE7CA-5021-40D8-81A3-AD0EEA264202Q28553258-18219506-53C0-47DC-95D3-DC5A566B488EQ30530476-D6C64254-9572-4DEA-87FF-981EB2E2BD7FQ33648748-E26E0206-F382-47E8-9365-36762F680B94Q33675820-40A07385-156F-494B-8965-C0D16BBF1386Q33859639-0609C917-D3C3-4D3E-B737-C883D2F0F57FQ33941171-A2995D35-8DCA-4A98-9351-3D9B317502F1Q34194314-34443B2E-EB28-489A-81E9-27C322C3C261Q34597491-5ADDF978-049B-40B4-8654-0BD8DCC1AD8BQ35046034-8843CEF5-48B2-429E-AF59-7C50C0AA1005Q35176553-DB04A9C3-055B-468D-AF83-1E4632C52CD3Q35384017-CF25C893-D8A4-470C-A120-DE6D047A36CEQ35434831-3C38F0CD-7C53-46FD-99FE-23D77C26BDF8Q35482558-44D71898-B5D0-4EFA-B86C-82F4BEB60BDAQ35743161-E1C98D25-99F7-4B7F-9611-B3A0F558DFFEQ35830489-B1104FED-0C52-448B-A3AA-D8756277C90EQ35899824-B14867A9-8ADE-43CF-A3F3-1F2D08008A16Q36070064-D6A7064C-E3F3-43E4-8D78-5A4957FCCE09Q36129573-6B4C2D60-3B8A-48F0-B01B-8811766B5C30Q36330973-4BDFFBDA-4759-403E-A298-704CE814494CQ36450695-25EDE53B-113B-4ED4-A199-AE24314A7E35Q36493255-E95499D5-F11E-4415-9276-FCB4F9473B1EQ36563357-0F1A3E7B-599E-4C9B-9300-259B1A0EC730Q36611416-409EAE8D-14E0-4C67-8F76-117D578E187DQ36770441-453F1AFD-6A30-4B7E-A655-A2DD9FB8E6C8Q37010736-4A26EAC6-BE71-42AC-A70B-F878D9C52FDEQ37488259-C4EB1421-5262-459D-80B3-0161177AC644Q37590328-0D01E502-4638-4C1E-9CE5-6A047677D3ACQ37632922-81B60582-92AA-44E4-B465-A85920C970F9Q37655085-52D82291-60D7-4CC1-96DD-7D7CD2FCD6FCQ37894832-491E281B-4712-4C50-ACE4-D0535ECB350BQ38803319-AE07E00F-9C28-4AE8-ABC9-231793F84986Q39179301-A922F1FC-B6B2-40E9-B215-8E3C06BE072AQ40337446-2ABDA8A8-DD0F-4DBB-AD88-AFA1ED5A196BQ41677287-19024035-D186-4FA9-8ADF-3986A0388215
P2860
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@en
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@nl
type
label
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@en
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@nl
prefLabel
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@en
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@nl
P2860
P356
P1476
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.
@en
P2093
Hiroshi Nikaido
Keiji Nagano
P2860
P304
P356
10.1073/PNAS.0901695106
P407
P577
2009-03-23T00:00:00Z