Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation.
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Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencingRecognition of multivalent histone states associated with heterochromatin by UHRF1 proteinRecombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescueNext-Generation Sequencing in the Understanding of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) BiologyBacteriophage-derived vectors for targeted cancer gene therapyMechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsMaintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complexThe site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivationTransitions in histone acetylation reveal boundaries of three separately regulated neighboring lociSIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cellsRelationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain.Role of cyclic AMP-dependent kinase response element-binding protein in recombinant adeno-associated virus-mediated transduction of heart muscle cells.Novel Tat-encoding bicistronic human immunodeficiency virus type 1-based gene transfer vectors for high-level transgene expression.Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator.Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivoAcetylation of a specific promoter nucleosome accompanies activation of the epsilon-globin gene by beta-globin locus control region HS2.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Chromatinization of the KSHV Genome During the KSHV Life Cycle.Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencingHigh-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms.Retrovirus silencer blocking by the cHS4 insulator is CTCF independent.Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response.Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle.Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA.Inhibition of histone deacetylation and DNA methylation improves gene expression mediated by the adeno-associated virus/phage in cancer cells.Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment.Intergenic transcription in the human beta-globin gene cluster.Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation.Antiglioma effects of combined use of a baculovirual vector expressing wild-type p53 and sodium butyrate.An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine.DNA methylation and histone modifications are the molecular lock in lentivirally transduced hematopoietic progenitor cells.Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening.Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain.Activation of silenced transgene expression in neural precursor cell lines by inhibitors of histone deacetylation.Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter.
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Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Molecular mechanism for silenc ...... on and chromatin condensation.
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Molecular mechanism for silenc ...... on and chromatin condensation.
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type
label
Molecular mechanism for silenc ...... on and chromatin condensation.
@en
Molecular mechanism for silenc ...... on and chromatin condensation.
@nl
prefLabel
Molecular mechanism for silenc ...... on and chromatin condensation.
@en
Molecular mechanism for silenc ...... on and chromatin condensation.
@nl
P2860
P356
P1476
Molecular mechanism for silenc ...... on and chromatin condensation.
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P2093
P2860
P304
P356
10.1073/PNAS.97.1.377
P407
P577
2000-01-01T00:00:00Z