Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
about
Cysteine-based regulation of the CUL3 adaptor protein Keap14-Hydroxy-nonenal-A Bioactive Lipid Peroxidation ProductEndogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic DerivativesThe basics of thiols and cysteines in redox biology and chemistryChemical approaches to detect and analyze protein sulfenic acidsLipid peroxidation and its toxicological implicationsA generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signalingSubstoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant responseThe electrophile responsive proteome: integrating proteomics and lipidomics with cellular functionQuantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylasesProtein adducts of aldehydic lipid peroxidation products identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometryProteomic profiling of acrolein adducts in human lung epithelial cellsLabel-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)T-REX on-demand redox targeting in live cells.Transduction of redox signaling by electrophile-protein reactionsCharacterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienalChemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe.Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid.Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome.A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c.Systems analysis of protein modification and cellular responses induced by electrophile stress.Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function.Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometryIdentification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease.Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesisQuantitative reactivity profiling predicts functional cysteines in proteomes.Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome.Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal.Exploring the biology of lipid peroxidation-derived protein carbonylation.Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adductionTo tag or not to tag: a comparative evaluation of immunoaffinity-labeling and tandem mass spectrometry for the identification and localization of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation.Site-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal.Integrated Haematological Profiles of Redox Status, Lipid, and Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity with Metabolic Syndrome.Interactions of glutathione transferases with 4-hydroxynonenal.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Formation and signaling actions of electrophilic lipidsLiver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular DamageProtein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.
P2860
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P2860
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 December 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
@en
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal.
@nl
type
label
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
@en
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal.
@nl
prefLabel
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
@en
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal.
@nl
P2093
P2860
P1476
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
@en
P2093
Bing Zhang
Dean D Billheimer
Scott M Sobecki
Simona G Codreanu
P2860
P304
P356
10.1074/MCP.M800070-MCP200
P577
2008-12-02T00:00:00Z