NF-kappa B p50-dependent in vivo footprints at Ig S gamma 3 DNA are correlated with mu-->gamma 3 switch recombination
about
Impaired B cell development and function in the absence of IkappaBNSShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Class-switch recombination: after the dawn of AID.Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factorActivation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashionTwo new isotype-specific switching activities detected for Ig class switching.Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switchingIdentification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.Switch region identity plays an important role in Ig class switch recombination.NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidneyIdentification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma.AID-dependent histone acetylation is detected in immunoglobulin S regions.Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia.
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NF-kappa B p50-dependent in vivo footprints at Ig S gamma 3 DNA are correlated with mu-->gamma 3 switch recombination
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2001
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
NF-kappa B p50-dependent in vi ...... ->gamma 3 switch recombination
@en
NF-kappa B p50-dependent in vi ...... >gamma 3 switch recombination.
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type
label
NF-kappa B p50-dependent in vi ...... ->gamma 3 switch recombination
@en
NF-kappa B p50-dependent in vi ...... >gamma 3 switch recombination.
@nl
prefLabel
NF-kappa B p50-dependent in vi ...... ->gamma 3 switch recombination
@en
NF-kappa B p50-dependent in vi ...... >gamma 3 switch recombination.
@nl
P2093
P2860
P1476
NF-kappa B p50-dependent in vi ...... ->gamma 3 switch recombination
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P2093
P2860
P304
P356
10.4049/JIMMUNOL.166.7.4552
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P577
2001-04-01T00:00:00Z