Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. - Wikidata - awgldk - TriplyDB

Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

http://www.wikidata.org/entity/Q37155438

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The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1 IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.Differential induction of innate immune responses by synthetic lipid a derivatives Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells.Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation IKKα negatively regulates ASC-dependent inflammasome activation.Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA.Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway.Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.Signaling in innate immunity and inflammation.SIGIRR, a negative regulator of colon tumorigenesis.The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production The structure function of the death domain of human IRAK-M.IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease.Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.IRAK2 is associated with susceptibility to rheumatoid arthritis.IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ.TRAF molecules in inflammation and inflammatory diseases.

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Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

http://www.wikidata.org/entity/Q37155438

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Interleukin-1 receptor-associa ...... post-transcriptional control.

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Interleukin-1 receptor-associa ...... post-transcriptional control.

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type

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Interleukin-1 receptor-associa ...... post-transcriptional control.

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Interleukin-1 receptor-associa ...... post-transcriptional control.

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prefLabel

Interleukin-1 receptor-associa ...... post-transcriptional control.

@en

Interleukin-1 receptor-associa ...... post-transcriptional control.

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Journal of Biological Chemistry

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Interleukin-1 receptor-associa ...... d post-transcriptional control

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Deborah Carlson

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George R Stark

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Hui Xiao

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James Thomas

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Jeremy Affolter

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Katarzyna Bulek

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Sujan Chaudhuri

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Tae Whan Kim

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Thomas Hamilton

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Xiaoxia Li

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P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

TLR6: A novel member of an expanding toll-like receptor family

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

A Toll-like receptor recognizes bacterial DNA

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

A family of human receptors structurally related to Drosophila Toll

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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10367-10375

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scholarly article

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10.1074/JBC.M807822200

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16

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284

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Barsanjit Mazumder

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2009-02-18T00:00:00Z

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19224918

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lipopolysaccharide

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2667724

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