Cells expressing anchorless prion protein are resistant to scrapie infection.
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Cellular aspects of prion replication in vitroRecombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivityGPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells.The role of the prion protein membrane anchor in prion infection.The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro.Propagation of RML prions in mice expressing PrP devoid of GPI anchor leads to formation of a novel, stable prion strainMonoacylated cellular prion protein modifies cell membranes, inhibits cell signaling, and reduces prion formation.Glycosylphosphatidylinositol anchor-dependent stimulation pathway required for generation of baculovirus-derived recombinant scrapie prion protein.Detection of the GPI-anchorless prion protein fragment PrP226* in human brain.Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion proteinMicrovesicles/exosomes as potential novel biomarkers of metabolic diseasesPrions and the potential transmissibility of protein misfolding diseasesPrions: Beyond a Single Protein.Identification of an intracellular site of prion conversion.A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner.PrP Knockout Cells Expressing Transmembrane PrP Resist Prion InfectionTaking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases.The GPI-anchoring of PrP: implications in sorting and pathogenesis.The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation.Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.Rapid cell-surface prion protein conversion revealed using a novel cell system.Prion propagation in cells expressing PrP glycosylation mutants.Cell Biology Approaches to Studying Prion Diseases.Proximity of SCG10 and prion protein in membrane rafts.In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding.The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication.Shedding light on prion disease.Establishment of a Madin-Darby bovine kidney cell line expressing anchorless bovine prion protein.
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Cells expressing anchorless prion protein are resistant to scrapie infection.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cells expressing anchorless prion protein are resistant to scrapie infection.
@en
Cells expressing anchorless prion protein are resistant to scrapie infection.
@nl
type
label
Cells expressing anchorless prion protein are resistant to scrapie infection.
@en
Cells expressing anchorless prion protein are resistant to scrapie infection.
@nl
prefLabel
Cells expressing anchorless prion protein are resistant to scrapie infection.
@en
Cells expressing anchorless prion protein are resistant to scrapie infection.
@nl
P2093
P2860
P356
P1433
P1476
Cells expressing anchorless prion protein are resistant to scrapie infection.
@en
P2093
Anne E Ward
Kristin L McNally
Suzette A Priola
P2860
P304
P356
10.1128/JVI.02412-08
P407
P577
2009-02-18T00:00:00Z