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Potassium Channels and Human Epileptic Phenotypes: An Updated OverviewOxidative Stress and Maxi Calcium-Activated Potassium (BK) ChannelsNeuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and PitfallsFunction and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cellsOn benzofuroindole analogues as smooth muscle relaxantsUp-Regulatory Effects of Curcumin on Large Conductance Ca2+-Activated K+ ChannelsThe Concise Guide to PHARMACOLOGY 2013/14: ion channelsUpregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsyBaifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels.Causes and consequences of hyperexcitation in central clock neurons.Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant.Molecular signatures of mouse TRPV1-lineage neurons revealed by RNA-Seq transcriptome analysis.Headache-type adverse effects of NO donors: vasodilation and beyondThe regulation of BK channel activity by pre- and post-translational modifications.NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology.BK channel activators and their therapeutic perspectivesCalcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chainRescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channelNeurogenic detrusor overactivity is associated with decreased expression and function of the large conductance voltage- and Ca(2+)-activated K(+) channelsEmerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation.In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activationMolecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.The LRRC26 protein selectively alters the efficacy of BK channel activators.Molecular mechanism of pharmacological activation of BK channels.Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels.Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels.Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord InjuryGlioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy.Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon.Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.Ca2+ -activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction.Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.Transduction of voltage and Ca2+ signals by Slo1 BK channels.Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
BK channel modulators: a comprehensive overview.
@en
BK channel modulators: a comprehensive overview.
@nl
type
label
BK channel modulators: a comprehensive overview.
@en
BK channel modulators: a comprehensive overview.
@nl
prefLabel
BK channel modulators: a comprehensive overview.
@en
BK channel modulators: a comprehensive overview.
@nl
P1476
BK channel modulators: a comprehensive overview.
@en
P2093
Antonio Nardi
Søren-Peter Olesen
P304
P356
10.2174/092986708784221412
P577
2008-01-01T00:00:00Z