Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding
about
A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPsX-ray structure of dopamine transporter elucidates antidepressant mechanismThe binding sites for cocaine and dopamine in the dopamine transporter overlapDesigning modulators of monoamine transporters using virtual screening techniquesBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNeurotransmitter and psychostimulant recognition by the dopamine transporter.Physiological characterisation of human iPS-derived dopaminergic neuronsTyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognitionSystematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disordersThe glial and the neuronal glycine transporters differ in their reactivity to sulfhydryl reagentsCloning and sequence analysis of cDNAs encoding the heavy and light chain variable regions of an Ab2beta anti-idiotypic monoclonal antibody possessing an internal image of cocaineRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersDominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicingClassic Studies on the Interaction of Cocaine and the Dopamine TransporterAssessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family.Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library.Drosophila rosA gene, which when mutant causes aberrant photoreceptor oscillation, encodes a novel neurotransmitter transporter homologue.Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity.Cloning and characterization of a potassium-coupled amino acid transporter.Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6.Infrared spectra of protonated neurotransmitters: dopamine.The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.A common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter.Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport.Early fluorescence signals detect transitions at mammalian serotonin transporters.Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties.Modification of the pH profile and tetrabenazine sensitivity of rat VMAT1 by replacement of aspartate 404 with glutamate.Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelProbes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole.Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeCloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster.Molecular mechanism of HIV-1 Tat interacting with human dopamine transporter.Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues.Molecular cloning of a putative vesicular transporter for acetylcholineChimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
P2860
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P2860
Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dopamine transporter site-dire ...... transport and cocaine binding
@en
Dopamine transporter site-dire ...... transport and cocaine binding.
@nl
type
label
Dopamine transporter site-dire ...... transport and cocaine binding
@en
Dopamine transporter site-dire ...... transport and cocaine binding.
@nl
prefLabel
Dopamine transporter site-dire ...... transport and cocaine binding
@en
Dopamine transporter site-dire ...... transport and cocaine binding.
@nl
P2093
P2860
P356
P1476
Dopamine transporter site-dire ...... transport and cocaine binding
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.16.7782
P407
P577
1992-08-01T00:00:00Z