Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
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Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations.
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Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
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scientific article published on 10 August 2015
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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Silencing of RUNX2 enhances ge ...... of TAp63-mediated cell death.
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P2093
P2860
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Silencing of RUNX2 enhances ge ...... n of TAp63-mediated cell death
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H Sugimoto
K Fujiwara
K Shinohara
M Nakamura
O Shimozato
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P2888
P356
10.1038/CDDISCOVERY.2015.10
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2015-08-10T00:00:00Z