Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. - Wikidata - awgldk - TriplyDB

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.

http://www.wikidata.org/entity/Q37168748

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Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Mutationally activated Rho GTPases in cancer Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments Rac1-dependent lamellipodial motility in prostate cancer PC-3 cells revealed by optogenetic control of Rac1 activity Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Regulation and function of P-Rex family Rac-GEFs Myopodin isoforms alter the chemokinetic response of PC3 cells in response to different migration stimuli via differential effects on Rho-ROCK signaling pathways NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.Conformational flexibility and binding interactions of the G protein βγ heterodimer.Gbetagamma signaling promotes breast cancer cell migration and invasion.P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells.Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth.The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells.Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Classifying ten types of major cancers based on reverse phase protein array profiles.Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes Rac signaling in breast cancer: a tale of GEFs and GAPs.The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.Synergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase.Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability.KIBRA promotes prostate cancer cell proliferation and motility.Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration.Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors.Deregulation of Rho GTPases in cancer

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Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.

http://www.wikidata.org/entity/Q37168748

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 23 March 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Upregulation of PIP3-dependent ...... es prostate cancer metastasis.

@en

Upregulation of PIP3-dependent Rac exchanger 1

@nl

type

label

Upregulation of PIP3-dependent ...... es prostate cancer metastasis.

@en

Upregulation of PIP3-dependent Rac exchanger 1

@nl

prefLabel

Upregulation of PIP3-dependent ...... es prostate cancer metastasis.

@en

Upregulation of PIP3-dependent Rac exchanger 1

@nl

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Upregulation of PIP3-dependent ...... es prostate cancer metastasis.

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B Wang

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D W Wolff

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F J Dowd

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J Qin

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J Zhao

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M A Scofield

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M Hoshino

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M-F Lin

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Y Tu

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Y Xie

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P2860

Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

The phosphoinositide 3-kinase pathway

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration

Cancer statistics, 2007

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

Metastasis: a therapeutic target for cancer.

Differential targeting of Gbetagamma-subunit signaling with small molecules.

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1853-1863

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scholarly article

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10.1038/ONC.2009.30

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16

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28

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2009-03-23T00:00:00Z

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19305425

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