Focal adhesion kinase versus p53: apoptosis or survival?
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FAK in cancer: mechanistic findings and clinical applicationsFAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.FAK dimerization controls its kinase-dependent functions at focal adhesionsTranscription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array.Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytesHigh focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsDentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells.Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular CarcinomaPharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsPhosphotyrosine profiling of curcumin-induced signaling.Targeting the p53 pathway.FAK overexpression and p53 mutations are highly correlated in human breast cancer.MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.FAK signalling controls insulin sensitivity through regulation of adipocyte survival.Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices.Focal adhesion kinase and p53 signal transduction pathways in cancer.Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.Focal adhesion kinase as a cancer therapy target.FAK and p53 protein interactions.FAK and Nanog cross talk with p53 in cancer stem cells.Targeting FAK in human cancer: from finding to first clinical trials.Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review.NANOG: a promising target for digestive malignant tumorsC-reactive protein binds to integrin α2 and Fcγ receptor I, leading to breast cell adhesion and breast cancer progression.Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt.Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells.Focal Adhesion Kinase a Potential Therapeutic Target for Pancreatic Cancer and Malignant Pleural Mesothelioma.Scaffold Proteins in Gastrointestinal Tumors as a Shortcut to Oncoprotein Activation.
P2860
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P2860
Focal adhesion kinase versus p53: apoptosis or survival?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Focal adhesion kinase versus p53: apoptosis or survival?
@en
Focal adhesion kinase versus p53: apoptosis or survival?
@nl
type
label
Focal adhesion kinase versus p53: apoptosis or survival?
@en
Focal adhesion kinase versus p53: apoptosis or survival?
@nl
prefLabel
Focal adhesion kinase versus p53: apoptosis or survival?
@en
Focal adhesion kinase versus p53: apoptosis or survival?
@nl
P2860
P356
P1433
P1476
Focal adhesion kinase versus p53: apoptosis or survival?
@en
P2093
Vita M Golubovskaya
William G Cance
P2860
P356
10.1126/STKE.120PE22
P577
2008-05-20T00:00:00Z