Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro - Wikidata - awgldk - TriplyDB

Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro

Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro

http://www.wikidata.org/entity/Q37169441

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Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease Shaping the role of mitochondria in the pathogenesis of Huntington's disease RCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal Apoptosis A central role for calcineurin in protein misfolding neurodegenerative diseases.Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels.Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.The Immunoproteasome in oxidative stress, aging, and disease.Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.Glucocorticoid-mediated co-regulation of RCAN1-1, E4BP4 and BIM in human leukemia cells susceptible to apoptosis.Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models.Critical role of regulator of calcineurin 1 in spinal cord injury.Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury.Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis.The role of declining adaptive homeostasis in ageing.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death.The Oxygen Paradox, the French Paradox, and age-related diseases.

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Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro

http://www.wikidata.org/entity/Q37169441

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 March 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

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name

Regulator of calcineurin (RCAN ...... t huntingtin toxicity in vitro

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Regulator of calcineurin

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type

label

Regulator of calcineurin (RCAN ...... t huntingtin toxicity in vitro

@en

Regulator of calcineurin

@nl

prefLabel

Regulator of calcineurin (RCAN ...... t huntingtin toxicity in vitro

@en

Regulator of calcineurin

@nl

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Journal of Biological Chemistry

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Regulator of calcineurin (RCAN ...... t huntingtin toxicity in vitro

@en

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Gennady Ermak

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Karl J Hench

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Kevin T Chang

http://www.w3.org/2001/XMLSchema#string

Sean Sachdev

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P2860

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors

A conserved family of calcineurin regulators.

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

ST14A cells have properties of a medium-size spiny neuron.

Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.

Calcium and oxidative stress: from cell signaling to cell death.

Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.

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11845-11853

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scholarly article

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10.1074/JBC.M900639200

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18

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284

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2009-03-06T00:00:00Z

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19270310

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Huntington disease

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2673253

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