Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. - Wikidata - awgldk - TriplyDB

Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.

Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.

http://www.wikidata.org/entity/Q37169881

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Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities Nuclear receptors and AMPK: resetting metabolism Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor Predictive features of ligand-specific signaling through the estrogen receptor Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.Chemical approaches to nuclear receptors in metabolism Use of phage display to identify novel mineralocorticoid receptor-interacting proteins.Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: addressing the "core issue" in the design of estrogen receptor ligands Peroxisome proliferator-activated receptors and cancer: challenges and opportunities Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer Research Resource: Androgen Receptor Activity Is Regulated Through the Mobilization of Cell Surface Receptor Networks.The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis Unravelling druggable signalling networks that control F508del-CFTR proteostasis Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges.New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Improving selective androgen receptor modulator discovery and preclinical evaluation.Sex, hormones and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications.Androgen Receptor Biology in Triple Negative Breast Cancer: a Case for Classification as AR+ or Quadruple Negative Disease.Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women.ELF3 is a repressor of androgen receptor action in prostate cancer cells A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells Rationale for the development of alternative forms of androgen deprivation therapy.Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1.The homeodomain protein HOXB13 regulates the cellular response to androgens.Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol.The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer.Recent discoveries and developments of androgen receptor based therapy for prostate cancer

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Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.

http://www.wikidata.org/entity/Q37169881

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2009

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vedecký článok

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name

Differential presentation of p ...... ical actions of bound ligands.

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Differential presentation of p ...... ical actions of bound ligands.

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Differential presentation of p ...... ical actions of bound ligands.

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Differential presentation of p ...... ical actions of bound ligands.

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Differential presentation of p ...... ical actions of bound ligands.

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Differential presentation of p ...... ical actions of bound ligands.

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J.CHEMBIOL.2009.01.016

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Chemistry and Biology

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Differential presentation of p ...... gical actions of bound ligands

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Andrea Barreto Sherk

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Ching-Yi Chang

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Daju Fan

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Dalia Juzumiene

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Delita Arnelle Dye

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Dmitri Kazmin

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Donald Patrick McDonnell

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Huaxia Cui

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James David Joseph

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John David Norris

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P2860

Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor

The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor

Supervillin associates with androgen receptor and modulates its transcriptional activity

Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF

Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)

Single-step purification of full-length human androgen receptor

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

Molecular basis of agonism and antagonism in the oestrogen receptor

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10.1016/J.CHEMBIOL.2009.01.016

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2009-04-01T00:00:00Z

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