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Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosisOncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signalingRIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosisApoptotic pathways as a therapeutic target for colorectal cancer treatmentTherapies targeting cancer stem cells: Current trends and future challengesThe structure of XIAP BIR2: understanding the selectivity of the BIR domainsTrailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer CellsCirculating TRAIL shows a significant post-partum decline associated to stressful conditionsModulating cell-to-cell variability and sensitivity to death ligands by co-drugging.Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmentCellular stress responses: cell survival and cell deathEmerging Bcl-2 inhibitors for the treatment of cancer.Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosisEarly growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells.Apoptotic death of cancer stem cells for cancer therapy.The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translationThe suppression of apoptosis by α-herpesvirus.Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathwaysAnalysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impactSub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways.TRAIL treatment provokes mutations in surviving cells.ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer.Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer MetastasisEmodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathwaymda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo.Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes.Characterization of Cholix toxin-induced apoptosis in HeLa cells.Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathwaysActivations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant.Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells.Combinatorial chemotherapeutic efficacy in non-Hodgkin lymphoma can be predicted by a signaling model of CD20 pharmacodynamicsTNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma xenografts.(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice.Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.How to target apoptosis signaling pathways for the treatment of pediatric cancersIntrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting the extrinsic apoptosis pathway in cancer.
@en
Targeting the extrinsic apoptosis pathway in cancer.
@nl
type
label
Targeting the extrinsic apoptosis pathway in cancer.
@en
Targeting the extrinsic apoptosis pathway in cancer.
@nl
prefLabel
Targeting the extrinsic apoptosis pathway in cancer.
@en
Targeting the extrinsic apoptosis pathway in cancer.
@nl
P1476
Targeting the extrinsic apoptosis pathway in cancer.
@en
P2093
Avi Ashkenazi
P304
P356
10.1016/J.CYTOGFR.2008.04.001
P577
2008-05-20T00:00:00Z