Variability and robustness in T cell activation from regulated heterogeneity in protein levels
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Networked buffering: a basic mechanism for distributed robustness in complex adaptive systemsCTLs respond with activation and granule secretion when serving as targets for T-cell recognitionExperimental and theoretical bases for mechanisms of antigen discrimination by T cellsCell-to-cell variability in cell death: can systems biology help us make sense of it all?Heterogeneity in immune responses: from populations to single cellsT cell responses to antigen: hasty proposals resolved through long engagementsGeneration of double-labeled reporter cell lines for studying co-dynamics of endogenous proteins in individual human cellsBarcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS)Deep Learning in Label-free Cell ClassificationA model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activatorsNoise propagation in two-step series MAPK cascadeExploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosisStochastic responses may allow genetically diverse cell populations to optimize performance with simpler signaling networksKinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation CycleHow MAP kinase modules function as robust, yet adaptable, circuitsBiological robustness: paradigms, mechanisms, and systems principlesModels of signalling networks - what cell biologists can gain from them and give to themSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsTemporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells.Polyfunctional responses by human T cells result from sequential release of cytokines.Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response.Data-driven quantification of the robustness and sensitivity of cell signaling networks.Stochastic sensitivity analysis and kernel inference via distributional data.Towards a rigorous assessment of systems biology models: the DREAM3 challengesRevitalizing personalized medicine: respecting biomolecular complexities beyond gene expression.Predicting CD62L expression during the CD8+ T-cell response in vivoA fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasisThe impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Evolution of acquired resistance to anti-cancer therapy.Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation.Perspectives for computer modeling in the study of T cell activationAdaptive informatics for multifactorial and high-content biological data.Origin of bistability underlying mammalian cell cycle entryPatterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes.Variability in G-protein-coupled signaling studied with microfluidic devices.Non-genetic cell-to-cell variability and the consequences for pharmacologyA simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells.Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback.
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Variability and robustness in T cell activation from regulated heterogeneity in protein levels
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Variability and robustness in ...... eterogeneity in protein levels
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Variability and robustness in ...... terogeneity in protein levels.
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type
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Variability and robustness in ...... eterogeneity in protein levels
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Variability and robustness in ...... terogeneity in protein levels.
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Variability and robustness in ...... eterogeneity in protein levels
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Variability and robustness in ...... terogeneity in protein levels.
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P2093
P2860
P356
P1433
P1476
Variability and robustness in ...... eterogeneity in protein levels
@en
P2093
Grégoire Altan-Bonnet
Joël Veiga
Ofer Feinerman
Ronald N Germain
P2860
P304
P356
10.1126/SCIENCE.1158013
P407
P577
2008-08-01T00:00:00Z