Telomere dysfunction and tumour suppression: the senescence connection
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First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meetingCohesin acetylation speeds the replication forkThe telomere syndromesRoles and mechanisms of cellular senescence in regulation of tissue homeostasisChange in peripheral blood leukocyte telomere length and mortality in breast cancer survivorsCTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustionGammaH2AX and cancerTelomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.Cancer biomarker discovery: the entropic hallmark.Telomeres and disease.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenitaRNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.Multiple roles for MRE11 at uncapped telomeres.Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-AnalysisTelomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.Telomere biology in healthy aging and disease.Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescenceTankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.Critically short telomeres and toxicity of chemotherapy in early breast cancerEffect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line.Akt regulates TPP1 homodimerization and telomere protection.Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences.CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1.Quantitative interpretation of a genetic model of carcinogenesis using computer simulationsIncreased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell lineThe diagnosis and treatment of dyskeratosis congenita: a review.A Cajal body-independent pathway for telomerase trafficking in mice.BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1.Beyond average: potential for measurement of short telomeres.Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsThe role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Bladder cancer in the elderly.New insights into p53 activationmiR-22 represses cancer progression by inducing cellular senescence
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Telomere dysfunction and tumour suppression: the senescence connection
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Telomere dysfunction and tumour suppression: the senescence connection
@en
Telomere dysfunction and tumour suppression: the senescence connection.
@nl
type
label
Telomere dysfunction and tumour suppression: the senescence connection
@en
Telomere dysfunction and tumour suppression: the senescence connection.
@nl
prefLabel
Telomere dysfunction and tumour suppression: the senescence connection
@en
Telomere dysfunction and tumour suppression: the senescence connection.
@nl
P2093
P2860
P356
P1476
Telomere dysfunction and tumour suppression: the senescence connection
@en
P2093
Sandy Chang
Suzanne S Chan
Yibin Deng
P2860
P2888
P304
P356
10.1038/NRC2393
P407
P577
2008-06-01T00:00:00Z