Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
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Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicityAcoustic trauma increases cochlear and hair cell uptake of gentamicin.Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection.Chemical screening for hair cell loss and protection in the zebrafish lateral lineLoss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephoneIntegrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death.Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea.Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss and regeneration.myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administrationSodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs.Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease.Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels.Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigsChanges in the adult vertebrate auditory sensory epithelium after trauma."In-bone" utricle cultures--a simplified, atraumatic technique for in situ cultures of the adult mouse (Mus musculus) utricle.Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.tmie Is required for gentamicin uptake by the hair cells of mice.Intracellular mechanisms of aminoglycoside-induced cytotoxicity.Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window.Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio)Live cell imaging of a fluorescent gentamicin conjugate.Systemic aminoglycosides are trafficked via endolymph into cochlear hair cellsProtection against noise-induced hearing loss in young CBA/J mice by low-dose kanamycinER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.New trends in aminoglycosides use.Spatially segregated transcription and translation in cells of the endomembrane-containing bacterium Gemmata obscuriglobusCompetitive antagonism of fluorescent gentamicin uptake in the cochleaInfection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin.Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell deathNatural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside ToxicityEffect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposureNatural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells.Rhodamine analogues for molecular ruler applications.Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigoActivation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea.
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Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 March 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@en
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@nl
type
label
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@en
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@nl
prefLabel
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@en
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.
@nl
P2860
P1433
P1476
Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells
@en
P2093
P2860
P2888
P304
P356
10.1007/S10162-009-0160-4
P577
2009-03-03T00:00:00Z