Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
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Sup35 methionine oxidation is a trigger for de novo [PSI(+)] prion formationRecombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivityManipulation of enzyme properties by noncanonical amino acid incorporation.A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindredEnolate Stabilization by Anion-π Interactions: Deuterium Exchange in Malonate Dilactones on π-Acidic Surfaces.Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.Structural and dynamic properties of the human prion protein.Ribosome-associated peroxiredoxins suppress oxidative stress-induced de novo formation of the [PSI+] prion in yeast.Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.Cell surface display yields evolvable, clickable antibody fragments.Norvaline and norleucine may have been more abundant protein components during early stages of cell evolution.Influence of pH on the human prion protein: insights into the early steps of misfolding.Convergent signaling pathways--interaction between methionine oxidation and serine/threonine/tyrosine O-phosphorylationMethionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathwayDisrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation.Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.Incorporation of unnatural amino acids for synthetic biology.Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications.In vivo incorporation of multiple noncanonical amino acids into proteins.Putting anion-π interactions into perspective.Modulating protein activity and cellular function by methionine residue oxidation.Designing protein-based biomaterials for medical applications.Methoxinine - an alternative stable amino acid substitute for oxidation-sensitive methionine in radiolabelled peptide conjugates.Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology.Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI+] prion.Autophagy protects against de novo formation of the [PSI+] prion in yeastImpact of methionine oxidation as an initial event on the pathway of human prion protein conversion.Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates.Homoisoleucine: a translationally active leucine surrogate of expanded hydrophobic surface area.On the lack of evolutionary continuity between prebiotic peptides and extant enzymes.Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results.Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure.Synthetic alienation of microbial organisms by using genetic code engineering: Why and how?Design of protein congeners containing β-cyclopropylalanine.Lipase Congeners Designed by Genetic Code EngineeringPosttranslational Modification of Proteins Incorporating Nonnatural Amino Acids
P2860
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P2860
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Design of anti- and pro-aggreg ...... dation in human prion protein.
@en
Design of anti- and pro-aggreg ...... dation in human prion protein.
@nl
type
label
Design of anti- and pro-aggreg ...... dation in human prion protein.
@en
Design of anti- and pro-aggreg ...... dation in human prion protein.
@nl
prefLabel
Design of anti- and pro-aggreg ...... dation in human prion protein.
@en
Design of anti- and pro-aggreg ...... dation in human prion protein.
@nl
P2093
P2860
P50
P356
P1476
Design of anti- and pro-aggreg ...... dation in human prion protein.
@en
P2093
Christina Wolschner
Hans A Kretzschmar
Robert Huber
P2860
P304
P356
10.1073/PNAS.0902688106
P407
P577
2009-04-28T00:00:00Z