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Visualizing cellular machines with colocalization single molecule microscopyFrameshifting dynamicsGTPase activation of elongation factor EF-Tu by the ribosome during decoding.Single-molecule FRET of protein structure and dynamics - a primer.Site-specific labeling of Saccharomyces cerevisiae ribosomes for single-molecule manipulations.Aminoglycoside activity observed on single pre-translocation ribosome complexes.Single-molecule analysis reveals three phases of DNA degradation by an exonuclease.A microfluidic approach for investigating the temperature dependence of biomolecular activity with single-molecule resolution.Single-molecule studies of the neuronal SNARE fusion machinery.O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteinsThe determination of tRNALeu recognition nucleotides for Escherichia coli L/F transferaseNavigating the ribosome's metastable energy landscapeProbing translation with small-molecule inhibitorsConformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome.Connecting energy landscapes with experimental rates for aminoacyl-tRNA accommodation in the ribosome.Revisiting the central dogma one molecule at a time.Tuning the affinity of aminoacyl-tRNA to elongation factor Tu for optimal decodingSkin transcriptome profiles associated with coat color in sheep.Functional consequences of T-stem mutations in E. coli tRNAThrUGU in vitro and in vivo.Excited states of ribosome translocation revealed through integrative molecular modeling.Exploring the balance between folding and functional dynamics in proteins and RNA.Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.Real-time evidence for EF-G-induced dynamics of helix 44 in 16S rRNA.Mechanistic insights into antibiotic action on the ribosome through single-molecule fluorescence imagingDesign and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation.Biomolecular dynamics: order-disorder transitions and energy landscapesSingle-molecule observations of ribosome functionThe structural dynamics of macromolecular processes.Fidelity at the molecular level: lessons from protein synthesis.Ribosome dynamics during decoding.From DNA to proteins via the ribosome: structural insights into the workings of the translation machinery.New structural insights into the decoding mechanism: translation infidelity via a G·U pair with Watson-Crick geometry.Photophysical processes in single molecule organic fluorescent probes.A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis.Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment.Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function.Kinetics of CrPV and HCV IRES-mediated eukaryotic translation using single molecule fluorescence microscopy.Constructing multi-resolution Markov State Models (MSMs) to elucidate RNA hairpin folding mechanismsSingle-molecule imaging of full protein synthesis by immobilized ribosomes.Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Translation at the single-molecule level.
@en
Translation at the single-molecule level.
@nl
type
label
Translation at the single-molecule level.
@en
Translation at the single-molecule level.
@nl
prefLabel
Translation at the single-molecule level.
@en
Translation at the single-molecule level.
@nl
P2093
P1476
Translation at the single-molecule level.
@en
P2093
Joseph D Puglisi
Magdalena Dorywalska
R Andrew Marshall
P304
P356
10.1146/ANNUREV.BIOCHEM.77.070606.101431
P577
2008-01-01T00:00:00Z