Cdk12 is essential for embryonic development and the maintenance of genomic stability. - Wikidata - awgldk - TriplyDB

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

http://www.wikidata.org/entity/Q37181671

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Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.Inhibitors of cyclin-dependent kinases as cancer therapeutics.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.The emerging roles of CDK12 in tumorigenesis.Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer.Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.

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Cdk12 is essential for embryonic development and the maintenance of genomic stability.

http://www.wikidata.org/entity/Q37181671

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 11 December 2015

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@en

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@nl

type

label

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@en

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@nl

prefLabel

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@en

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

@nl

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Cell Death & Differentiation

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Cdk12 is essential for embryonic development and the maintenance of genomic stability.

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H-C Juan

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H-R Chen

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M-J Fann

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Y Lin

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P2860

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II

Homologous recombination in DNA repair and DNA damage tolerance

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

Integrated genomic analyses of ovarian carcinoma

DNA double-strand breaks: signaling, repair and the cancer connection

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells

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1038-1048

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scholarly article

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10.1038/CDD.2015.157

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