DNA double-strand breaks: signaling, repair and the cancer connection
about
sameAs
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repairHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityInhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosisDNA double-strand breaks by asbestos, silica, and titanium dioxideStructure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structureIn vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexA YY1-INO80 complex regulates genomic stability through homologous recombination-based repairPML colocalizes with and stabilizes the DNA damage response protein TopBP1The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targetsHighlight: BRCA1 and BRCA2 proteins in breast cancerWSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityMolecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testisHSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage responseN terminus of CtIP is critical for homologous recombination-mediated double-strand break repairRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringRegulation of TIP60 by ATF2 modulates ATM activationA role for DEAD box 1 at DNA double-strand breaksSuppression of nonhomologous end joining repair by overexpression of HMGA2Involvement of human MOF in ATM functionHuman MMS21/NSE2 is a SUMO ligase required for DNA repairDisruption of mechanisms that prevent rereplication triggers a DNA damage responseA role for RAD54B in homologous recombination in human cellsShorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repairThe DNA-damage response in human biology and diseaseMicroRNA-182-5p targets a network of genes involved in DNA repairA polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cellDegradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damageRecombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional AnalysisDNA damage response and Ku80 function in the vertebrate embryo.No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancerFrequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer familiesCharacterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.Bystander effects in UV-induced genomic instability: antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiationInhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repairAging of hematopoietic stem cells: DNA damage and mutations?Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection PathwaysThe DNA damage response induced by infection with human cytomegalovirus and other virusesGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsIntroduction to radiobiology of targeted radionuclide therapy
P2860
Q21145054-7111F3A7-A121-488B-9B8B-C73E3C55F079Q21263027-78E6A496-5EEC-4740-A2F6-ECE556A1D819Q23913433-1C106ABA-7D4C-480E-A573-18E50CC7D633Q23924230-5A9F1DDE-CDCB-4435-9052-F1BF5D84AC97Q24292396-2B608A8C-DA4D-4705-BDEC-6663CA1E7AA7Q24294826-B4A2F54F-D55D-4D97-8F33-5F07C899A0BEQ24300998-AA72B283-CC8D-425B-9220-0958BAC5B6BFQ24303540-68FF312F-67D7-48BC-8B4E-2A73F919A2DEQ24304999-15E2BDBD-7415-4B82-A3F7-6282BB365461Q24307401-6AF0D151-FC8C-4118-820D-B2D9DCE394FCQ24309061-9F11F2A7-1116-42F6-9B5C-2AE948AD879EQ24314462-A0E686F0-405D-4FE5-B9A1-4A66B0CB63E5Q24314871-86BB39A6-B35C-4C64-ACDE-8C8BA1FD2132Q24316509-4E4D4F8B-BC1B-43EE-9902-4F07C9B95AAAQ24317537-B3FD2468-E4E7-4FA3-AE45-BC672B842951Q24318454-ECA856C5-8861-4A61-86D2-AB0F921B3826Q24323911-8EE9D474-0E5F-47FF-B529-8E328387ACE3Q24338991-2FD4C102-561C-44D6-97F8-CCAC51272F09Q24529072-FCF81485-7B68-4449-8C9A-C18067AC0EA2Q24529887-3AB07657-C230-42CA-AA0C-0018BB17EA48Q24529993-2CE7A603-5AC3-4E66-9432-AE5E8A59AA62Q24536135-9CC76F3B-FC6F-43FD-BF4D-726FA76D42B0Q24537136-A23E4CDC-0C1A-47DD-85AF-118979DFA1C6Q24603375-EA79D1FA-A8F2-447F-83AC-BD2B9ADE047AQ24606586-194E36F6-F6EA-4A5B-8F31-340AFEF90E41Q24633326-BCCF65E3-0D0B-471E-AB09-9988C4507F00Q24649958-2B9FC988-EC39-4179-9CD2-271EE71231B6Q24653338-CD269240-8E64-4607-81B7-9F473BDBDAF0Q24680716-1AF97C3F-21B6-49A1-B585-055DCB78AEBDQ24794313-C2C14D39-5B87-49B2-B477-ABD32D77CED5Q24800108-2C95CC5C-92B8-4BF1-8B44-5849CEAC5984Q24806235-75314A08-F031-4033-AB37-6545EEB158BAQ24813163-48B99A95-3388-4A92-AF41-71569BBF4F64Q24816263-943A70A7-65E2-4232-B0AE-2447B39C121CQ25257863-3B8B4514-A90D-47E4-8BA2-36A46559B6DEQ26741217-004151EC-2CA4-4407-BCDD-8F1AD93A9039Q26742114-8841E696-7038-49E2-83A1-3C6D0A46226FQ26825363-0A7DB2F0-6B95-45AC-9928-AE4C6FB22A3CQ26851196-03E69AF7-B01A-4A51-A52E-B63ACD3985E2Q26852029-D9825E4F-2EDC-4F6A-AA1E-71996AD5076A
P2860
DNA double-strand breaks: signaling, repair and the cancer connection
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
DNA double-strand breaks: signaling, repair and the cancer connection
@ast
DNA double-strand breaks: signaling, repair and the cancer connection
@en
DNA double-strand breaks: signaling, repair and the cancer connection
@nl
type
label
DNA double-strand breaks: signaling, repair and the cancer connection
@ast
DNA double-strand breaks: signaling, repair and the cancer connection
@en
DNA double-strand breaks: signaling, repair and the cancer connection
@nl
prefLabel
DNA double-strand breaks: signaling, repair and the cancer connection
@ast
DNA double-strand breaks: signaling, repair and the cancer connection
@en
DNA double-strand breaks: signaling, repair and the cancer connection
@nl
P3181
P356
P1433
P1476
DNA double-strand breaks: signaling, repair and the cancer connection
@en
P2093
P2888
P304
P3181
P356
10.1038/85798
P407
P577
2001-03-01T00:00:00Z